Host cell phenotypic variability induced by trypanosomatid-parasite-released immunomodulatory factors: Physiopathological implications

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2004

Autores

Ouaissi, A (Autor) Outra; Ouaissi, M (Autor) Outra; Tavares, J (Autor) FFUP; Cordeiro Da Silva, A (Autor) FFUP

Revista

Título: Journal of Biomedicine and Biotechnology

Vol. 2004

Páginas: 167-174

ISSN: 1110-7243

Editora: HINDAWI PUBLISHING CORPORATION

Indexação

ISI Web of Knowledge - 7 Citações

Scopus - 8 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Outras ciências médicas

Outras Informações

ID Authenticus: P-000-9CW

DOI: 10.1155/s1110724304311034

Abstract (EN): The parasitic protozoa Trypanosoma cruzi and Leishmania sp release a variety of molecules into their mammalian hosts (ESA: excretory-secretory products). The effects of these ESA on the host cell function may participate in the establishment of a successful infection, in which the parasite persists for a sufficient period of time to complete its life cycle. A number of regulatory components or processes originating from the parasite that control or regulate the metabolism and the growth of host cell have been identified. The purpose of the present review is to analyze some of the current data related to the parasite ESA that interfere with the host cell physiology. Special attention is given to members of conserved protein families demonstrating remarkable diversity and plasticity of function (ie, glutathione S-transferases and related molecules; members of the trans-sialidase and mucin family; and members of the ribosomal protein family). The identification of parasite target molecules and the elucidation of their mode of action toward the host cell represents a step forward in efforts aimed at an immunotherapeutic or pharmacological control of parasitic infection.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8