A new model for the transmission of Helicobacter pylori: Role of environmental reservoirs as gene pools to increase strain diversity

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2007

Autores

Azevedo, NF (Autor) Outra; Guimaraes, N (Autor) Outra; Figueiredo, C (Autor) FMUP; Keevil, CW (Autor) Outra; Vieira, MJ (Autor) Outra

Revista

Título: Critical Reviews in Microbiology

Vol. 33

Páginas: 157-169

ISSN: 1040-841X

Editora: Taylor & Francis

Indexação

ISI Web of Knowledge - 34 Citações

Scopus - 42 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Ciências biológicas

Outras Informações

ID Authenticus: P-004-CW7

DOI: 10.1080/10408410701451922

Abstract (EN): Twenty-five years after the first successful cultivation and isolation of Helicobacter pylori, the scientific community is still struggling to understand the way(s) this bacterium is transmitted among the human population. Here, both epidemiologic and microbiologic evidence addressing this matter is reviewed and explored to conclude that most H. pylori successful colonizations are derived from direct person-to-person contact and that even though exposure of humans to H. pylori from environmental sources is a very common event, in most occasions the host is able to fight off infection. In addition, under a new model developed here, we propose that the near elimination of environmental reservoirs is the main responsible for the lower prevalence observed in the more industrialized countries by acting on two levels: by decreasing the number of direct infections and by diminishing the number of intraspecies recombination events for producing strain variation within H. pylori.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 13