Folates and aging: Role in mild cognitive impairment, dementia and depression

• Tipo: Artigo em Revista Científica Internacional
• Data: 2015

Autores

Araujo, J.R. (Autor) Outra; Martel, F. (Autor) FMUP; Borges, Nuno (Autor) FCNAUP; Araujo, J.M (Autor) Outra; Keating, E. (Autor) Outra

Revista

Título: Ageing Research Reviews

Vol. 22

Páginas: 9-19

ISSN: 1568-1637

Editora: Elsevier

Indexação

ISI Web of Knowledge - 98 Citações

ISI Web of Science

Scopus - 119 Citações

Classificação Científica

CORDIS: Ciências da Saúde

FOS: Ciências médicas e da saúde

Outras Informações

ID Authenticus: P-00G-3JE

DOI: 10.1016/j.arr.2015.04.005

Abstract (EN): In almost all tissues, including the brain, folates are required for one-carbon transfer reactions, which are essential for the synthesis of DNA and RNA nucleotides, the metabolism of amino acids and the occurrence of methylation reactions. The aim of this paper is to review the impact of folate status on the risk of development of neuropsychiatric disorders in older individuals. The prevalence of folate deficiency is high among individuals aged >= 65 years mainly due to reduced dietary intake and intestinal malabsorption. Population-based studies have demonstrated that a low folate status is associated with mild cognitive impairment, dementia (particularly Alzheimer's disease) and depression in healthy and neuropsychiatric diseased older individuals. The proposed mechanisms underlying that association include hyperhomocysteinemia, lower methylation reactions and tetrahydrobiopterin levels, and excessive mis-incorporation of uracil into DNA. However, currently, there is no consistent evidence demonstrating that folic acid supplementation improves cognitive function or slows cognitive decline in healthy or cognitively impaired older individuals. In conclusion, folate deficiency seems to be an important contributor for the onset and progression of neuropsychiatric diseases in the geriatric population but additional studies are needed in order to increase the knowledge of this promising, but still largely unexplored, area of research. (C) 2015 Elsevier B.V. All rights reserved.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

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