Phlorotannin Extracts from Fucales Characterized by HPLC-DAD-ESI-MSn: Approaches to Hyaluronidase Inhibitory Capacity and Antioxidant Properties

• Tipo: Artigo em Revista Científica Internacional
• Data: 2012

Autores

Federico Ferreres (Autor) Outra; Graciliana Lopes (Autor) Outra; Angel Gil Izquierdo (Autor) Outra; Paula B Andrade (Autor) FFUP; Carla Sousa (Autor) FFUP; Teresa Mouga (Autor) Outra; Patricia Valentao (Autor) FFUP

Revista

Título: Marine Drugs

Vol. 10 Nº 10

Páginas: 2766-2781

ISSN: 1660-3397

Editora: MDPI

Indexação

ISI Web of Knowledge - 63 Citações

ISI Web of Science

Scopus - 121 Citações

Classificação Científica

CORDIS: Ciências da Saúde

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-002-2RF

DOI: 10.3390/md10122766

Abstract (EN): Purified phlorotannin extracts from four brown seaweeds (Cystoseira nodicaulis (Withering) M. Roberts, Cystoseira tamariscifolia (Hudson) Papenfuss, Cystoseira usneoides (Linnaeus) M. Roberts and Fucus spiralis Linnaeus), were characterized by HPLC-DAD-ESI-MSn. Fucophloroethol, fucodiphloroethol, fucotriphloroethol, 7-phloroeckol, phlorofucofuroeckol and bieckol/dieckol were identified. The antioxidant activity and the hyaluronidase (HAase) inhibitory capacity exhibited by the extracts were also assessed. A correlation between the extracts activity and their chemical composition was established. F. spiralis, the species presenting higher molecular weight phlorotannins, generally displayed the strongest lipid peroxidation inhibitory activity (IC50 = 2.32 mg/mL dry weight) and the strongest HAase inhibitory capacity (IC50 = 0.73 mg/mL dry weight). As for superoxide radical scavenging, C. nodicaulis was the most efficient species (IC50 = 0.93 mg/mL dry weight), followed by F. spiralis (IC50 = 1.30 mg/mL dry weight). These results show that purified phlorotannin extracts have potent capabilities for preventing and slowing down the skin aging process, which is mainly associated with free radical damage and with the reduction of hyaluronic acid concentration, characteristic of the process.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 16