Clear Cell Change in Colonic Polyps

• Tipo: Artigo em Revista Científica Internacional
• Data: 2009

Autores

Catarina Eloy (Autor) FMDUP; Jose M Lopes (Autor) FMUP; Gil Faria (Autor) Outra; Herculano Moreira (Autor) Outra; Abilio Brandao (Autor) Outra; Teresa Silva (Autor) Outra; Fatima Carneiro (Autor) FMUP

Revista

Título: International Journal of Surgical Pathology

Vol. 17

Páginas: 438-443

ISSN: 1066-8969

Editora: SAGE

Indexação

ISI Web of Knowledge - 16 Citações

Scopus - 16 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-003-DZE

DOI: 10.1177/1066896908319211

Abstract (EN): In this study, the pathogenesis of clear cell change in colorectal epithelial lesions was studied. A total of 4 cases of clear cell change (1 hyperplasic polyp and 3 adenomas) were characterized using histochemistry, immunohistochemistry, and electron microscopy. All lesions developed in the left colon. In all, I adenoma with clear cell dysplastic glands progressed to adenocarcinoma without clear cell change. Clear cell cytoplasmatic vacuoles were negative for glycogen and mucins (MUC 2, MUC 5AC). Ki-67 LI in clear cell adenoma components was lower than in common adenoma components of the same dysplasia grades (while p53 and beta-catenin were similarly expressed). Ultrastructural features of clear cell change showed features of lipid-like material. Clear cell change is found in hyperplastic and neoplastic lesions of the colon and is not due to the accumulation of glycogen or mucins. A degenerative nature of clear cell change is suggested by the demonstration of lipid-like material in the vacuoles of clear cells.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6