TP53 codon 72 polymorphism and risk for cervical cancer in Portugal

• Tipo: Artigo em Revista Científica Internacional
• Data: 2005

Autores

Santos, AM (Autor) Outra; Sousa, H (Autor) Outra; Catarino, R (Autor) Outra; Pinto, D (Autor) Outra; Pereira, D (Autor) Outra; Vasconcelos, A (Autor) Outra; Matos, A (Autor) Outra; Lopes, C (Autor) ICBAS; Medeiros, R (Autor) ICBAS

Revista

Título: Cancer Genetics and Cytogenetics

Vol. 159

Páginas: 143-147

ISSN: 0165-4608

Editora: Elsevier B.V.

Indexação

ISI Web of Knowledge - 38 Citações

Scopus - 37 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina clínica

Outras Informações

ID Authenticus: P-000-2YN

DOI: 10.1016/j.cancergencyto.2004.10.005

Abstract (EN): High-risk human papillomavirus are essential for the development of cervical cancer; however, TP53 is the most frequently altered tumor suppressor gene among tumors and is described as a cofactor for cervical carcinogenesis. TP53 has two common polymorphic forms encoding either proline or arginine, at position 72, and the presence of homozygous arginine has been reported as a risk factor for cervical cancer in many populations. We evaluated the effect of this TP53 polymorphism in a northern Portuguese population. We analyzed blood samples of 385 women; 20 with low-grade squamous intraepithelial lesion (SIL), 56 with high-grade SIL, 164 with invasive cervical cancer, and 145 healthy controls, using allele specific-polymerase chain reaction methodology. We observed an increased frequency of the Arg/Arg genotype in the cancer group, but no statistical significance was found between cases and controls (P > 0.05). Our results indicate that there is no association between the presence of the Arg allele in codon 72 of TP53 polymorphism and risk of cervical cancer in our population.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5