Red Wine Protects against Ethanol-Induced Oxidative Stress in Rat Liver

• Tipo: Artigo em Revista Científica Internacional
• Data: 2009

Autores

Marco Assuncao (Autor) Outra; Maria J Santos Marques (Autor) FMUP; Rosario Monteiro (Autor) FMUP; Isabel Azevedo (Autor) Outra; Jose P Andrade (Autor) FMUP; Felix Carvalho (Autor) FFUP; Maria J Martins (Autor) FMUP

Revista

Título: Journal of Agricultural and Food Chemistry

Vol. 57 Nº 19

Páginas: 6066-6073

ISSN: 0021-8561

Editora: American Chemical Society

Indexação

ISI Web of Knowledge - 21 Citações

ISI Web of Science

Scopus - 24 Citações

Classificação Científica

FOS: Ciências agrárias > Outras ciências agrárias

Outras Informações

ID Authenticus: P-003-HF0

DOI: 10.1021/jf900576h

Abstract (EN): Ethanol consumption may be deleterious to the liver. However, alcoholic beverages contain, besides ethanol (EtOH), complex chemical mixtures that can modify EtOH's adverse effects. Red wine (RW) is rich in polyphenolic antioxidants, often reported as hepatoprotective agents. This study aimed to investigate the effects of 6 months of RW ingestion on hepatic oxidative stress and inflammation. Six-month-old Wistar rats were treated with RW or EtOH; controls were pair-fed. EtOH increased 8-hydroxy-2'-deoxyguanosine and decreased reduced and oxidized glutathione. These animals also displayed stimulated superoxide dismutase, catalase, and glutathione reductase activities. RW treatment decreased malondialdehyde and reduced glutathione levels. Glutathione-S-transferase and selenium-dependent glutathione peroxidase activities were stimulated and glutathione reductase activity was inhibited by RW intake. No modifications were detected in nuclear factor-kappa B or alkaline phosphatase activities. EtOH consumption induced fibrosis in portal spaces and hepatocyte lipid accumulation that were absent with RW treatment. This paper highlights the importance of RW nonalcoholic components and the relevance of biological matrix in the study of EtOH oxidative effects.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8