Protective role of the HLA-A*02 allele in Portuguese patients with multiple sclerosis

• Tipo: Artigo em Revista Científica Internacional
• Data: 2009

Autores

Silva, AM (Autor) Outra; Bettencourt, A (Autor) Outra; Pereira, C (Autor) Outra; Santos, E (Autor) Outra; Carvalho, C (Autor) Outra; Mendonca, D (Autor) ICBAS; Costa, PP (Autor) ICBAS; Monteiro, L (Autor) Outra; Martins, B (Autor) Outra

Revista

Título: Multiple Sclerosis Journal

Vol. 15

Páginas: 771-774

ISSN: 1352-4585

Editora: SAGE

Indexação

ISI Web of Knowledge - 16 Citações

Scopus - 18 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina clínica

Outras Informações

ID Authenticus: P-003-JVH

DOI: 10.1177/1352458509104588

Abstract (EN): Background Multiple sclerosis (MS) is associated with human leukocyte antigen (HLA) HLA DRB1*15. Recent evidence that CD8 T cells are implicated in MS suggests that HLA class I may also contribute. An association of HLA-A*02 and A*03 alleles has been described. Objectives We examined the influence of HLA-A*02 and HLA-A*03 in Portuguese patients with MS, independently of HLA-DRB1*15 using a logistic regression model. Conclusions DRB1*15 increased the risk of developing MS and HLA-A*02 decreased the risk. A*03 had no effect. To analyze if HLA-A*02 association was independent from DRB1*15, an interaction between these two alleles was introduced in the model; no significant interaction was found. Multiple Sclerosis 2009; 15: 771-774. http://msj.sagepub.com

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 4