Receptor-drug association studies in the inhibition of the hematin aggregation process of malaria

• Tipo: Artigo em Revista Científica Internacional
• Data: 2003

Autores

Portela, C (Autor) Outra; Afonso, CMM (Autor) FFUP; Pinto, MMM (Autor) FFUP; Ramos, MJ (Autor) FCUP

Revista

Título: FEBS Letters

Vol. 547

Páginas: 217-222

ISSN: 0014-5793

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 36 Citações

Scopus - 40 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Ciências biológicas

Outras Informações

ID Authenticus: P-000-FVV

DOI: 10.1016/s0014-5793(03)00692-6

Abstract (EN): Docking studies were performed to investigate the binding of several antimalarial compounds to the putative drug receptors involved in the hematin aggregation process. These studies reveal a binding profile that correlates with the complementarity of electrostatic potentials between the receptors and the active molecules. These results allow a possible explanation for the same molecular mechanism shown by 4-aminoquinolines, quinine, mefloquine, halofantrine and hydroxylated xanthones. The docking data presented in this work offer an interesting approach to the design of new molecules with potential antimalarial activity.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6