Role of host cell traversal by the malaria sporozoite during liver infection

• Tipo: Artigo em Revista Científica Internacional
• Data: 2013

Autores

Joana Tavares (Autor) Outra; Formaglio, P (Autor) Outra; Thiberge, S (Autor) Outra; Mordelet, E (Autor) Outra; Van Rooijen, N (Autor) Outra; Medvinsky, A (Autor) Outra; Menard, R (Autor) Outra; Amino, R (Autor) Outra

Revista

Título: Journal of Experimental Medicine

Vol. 210

Páginas: 905-915

ISSN: 0022-1007

Editora: Rockefeller University Press

Indexação

ISI Web of Knowledge - 71 Citações

Scopus - 105 Citações

Outras Informações

ID Authenticus: P-005-0T0

DOI: 10.1084/jem.20121130

Abstract (EN): Malaria infection starts when the sporozoite stage of the Plasmodium parasite is injected into the skin by a mosquito. Sporozoites are known to traverse host cells before finally invading a hepatocyte and multiplying into erythrocyte-infecting forms, but how sporozoites reach hepatocytes in the liver and the role of host cell traversal (CT) remain unclear. We report the first quantitative imaging study of sporozoite liver infection in rodents. We show that sporozoites can cross the liver sinusoidal barrier by multiple mechanisms, targeting Kupffer cells (KC) or endothelial cells and associated or not with the parasite CT activity. We also show that the primary role of CT is to inhibit sporozoite clearance by KC during locomotion inside the sinusoid lumen, before crossing the barrier. By being involved in multiple steps of the sporozoite journey from the skin to the final hepatocyte, the parasite proteins mediating host CT emerge as ideal antibody targets for vaccination against the parasite.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 11