Bone marrow contribution to the heart from development to adulthood

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2020

Autores

Sampaio Pinto, V (Autor) Outra; Ruiz Villalba, A (Autor) Outra; Nascimento, DS (Autor) ICBAS; Pérez Pomares, JM (Autor) Outra

Revista

A Revista está pendente de validação pelos Serviços Administrativos.

Título: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Vol. 112

Páginas: 16-26

ISSN: 1084-9521

Editora: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD

Indexação

Scopus - 1 Citação

Outras Informações

ID Authenticus: P-00S-CER

DOI: 10.1016/j.semcdb.2020.06.008

Abstract (EN): Cardiac chamber walls contain large numbers of non-contractile interstitial cells, including fibroblasts, endothelial cells, pericytes and significant populations of blood lineage-derived cells. Blood cells first colonize heart tissues a few days before birth, although their recruitment from the bloodstream to the cardiac interstitium is continuous and extends throughout adult life. The bone marrow, as the major hematopoietic site of adult individuals, is in charge of renewing all circulating cell types, and it therefore plays a pivotal role in the incorporation of blood cells to the heart. Bone marrow-derived cells are instrumental to tissue homeostasis in the steady-state heart, and are major effectors in cardiac disease progression. This review will provide a comprehensive approach to bone marrow-derived blood cell functions in the heart, and discuss aspects related to hot topics in the cardiovascular field like cell-based heart regeneration strategies. © 2020 Elsevier Ltd

Idioma: Inglês

Tipo (Avaliação Docente): Científica