Caspase-3 and bcl-2 expression in aging in adrenal zona reticularis after dexamethasone administration

• Tipo: Artigo em Revista Científica Internacional
• Data: 2007

Autores

Henrique Almeida (Autor) FMUP; Liliana Matos (Autor) FCNAUP; Delminda Neves (Autor) FMUP

Revista

Título: Annals of the New York Academy of Sciences

Vol. 1119

Páginas: 190-195

ISSN: 0077-8923

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 1 Citação

ISI Web of Science

Scopus - 0 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina clínica

CORDIS: Ciências da Saúde > Ciências Médicas > Medicina > Endocrinologia ; Ciências Naturais > Ciências biológicas > Biologia > Biologia celular

Outras Informações

ID Authenticus: P-004-DYW

DOI: 10.1196/annals.1404.021

Abstract (EN): Adrenocortical cell death by apoptosis is a common finding when adrenocorticotropic hormone is suppressed. Despite the well-known final structural features exhibited by those cells, data on the mechanisms preceding these final events are lacking. In this study, after 3 days of dexamethasone administration to rats of different ages, rat adrenals were processed for immunocytochemical study. In the zona reticularis, there was evidence of the activation of Bcl-2 and caspase-3 proteins. Beyond a small age-related increase in labeled cells, the number of cells presenting colocalization for both proteins was noteworthy. The results confirm the involvement of Bcl-2 and caspase-3 proteins in the apoptotic pathway and suggest their simultaneous intervention.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6