GWAS contribution to atrial fibrillation and atrial fibrillation-related stroke: pathophysiological implications

• Tipo: Artigo em Revista Científica Internacional
• Data: 2019

Autores

Cruz, D (Autor) Outra; Pinto, R (Autor) Outra; Freitas Silva, M (Autor) FMUP; José Pedro Nunes (Autor) FMUP; Rui Medeiros (Autor) ICBAS

Revista

Título: Pharmacogenomics

Vol. 20

Páginas: 765-780

ISSN: 1462-2416

Editora: ASHLEY PUBLICATIONS LTD

Indexação

ISI Web of Knowledge - 6 Citações

Scopus - 6 Citações

Outras Informações

ID Authenticus: P-00Q-YZ5

DOI: 10.2217/pgs-2019-0054

Abstract (EN): Atrial fibrillation (AF) and stroke are included in a group of complex traits that have been approached regarding of their study by susceptibility genetic determinants. Since 2007, several genome-wide association studies (GWAS) aiming to identify genetic variants modulating AF risk have been conducted. Thus, 11 GWAS have identified 26 SNPs (p <5x 10(-2)), of which 19 reached genome-wide significance (p <5x10(-8)). From those variants, seven were also associated with cardioembolic stroke and three reached genome-wide significance in stroke GWAS. These associations may shed a light on putative shared etiologic mechanisms between AF and cardioembolic stroke. Additionally, some of these identified variants have been incorporated in genetic risk scores in order to elucidate new approaches of stroke prediction, prevention and treatment.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 16