Anti-inflammatory choline based ionic liquids: Insights into their lipophilicity, solubility and toxicity parameters

• Tipo: Artigo em Revista Científica Internacional
• Data: 2017

Autores

Azevedo, AMO (Autor) Outra; Costa, SPF (Autor) Outra; Dias, AFV (Autor) Outra; Marques, AHO (Autor) Outra; Pinto, PCAG (Autor) Outra; Bica, K (Autor) Outra; Ressmann, AK (Autor) Outra; Passos, MLC (Autor) Outra; Araujo, ARTS (Autor) Outra; Salette Reis (Autor) FFUP; Lucia L M F S Saraiva (Autor) FFUP

Revista

Título: Journal of Molecular Liquids

Vol. 232

Páginas: 20-26

ISSN: 0167-7322

Editora: Elsevier

Indexação

ISI Web of Knowledge - 6 Citações

Scopus - 17 Citações

Outras Informações

ID Authenticus: P-00M-R6W

DOI: 10.1016/j.molliq.2017.02.027

Abstract (EN): The impact on in vivo efficacy and safety of two novel ionic liquids based on the association of choline with non steroidal anti-inflammatory drugs, ketoprofen and naproxen forming IL-APIs, was evaluated. Their lipophilicity, solubility and toxicity were assessed aiming the illustration of the pharmaceutical profile and potential toxic impact. Partition coefficient was determined using micelles of hexadecylphosphocholine and UV-Vis derivative spectroscopy. Additionally, solubility in phosphate buffer pH 7.4 was measured using a modified shake flask method and UV-Vis spectroscopy as detection technique. Ultimately, toxicity was considered resorting to a fully automated cytochrome c oxidase assay based on microfluidics. The obtained results demonstrated that the IL-APIs' drug format has the ability to interact with biological membranes and also improves solubility up to 58 times. Moreover, it was evidenced that, although being a nutrient, choline influences the IL-APIs' toxicity. The studied anti-inflammatory IL-APIs exhibited promising properties regarding their incorporation in pharmaceutical formulations.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7