The spindle assembly checkpoint: Preventing chromosome mis-segregation during mitosis and meiosis

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2006

Autores

Malmanche, N (Autor) Outra; Maia, A (Autor) Outra; Sunkel, CE (Autor) ICBAS

Revista

Título: FEBS Letters

Vol. 580

Páginas: 2888-2895

ISSN: 0014-5793

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 55 Citações

Scopus - 65 Citações

Outras Informações

ID Authenticus: P-004-KQS

DOI: 10.1016/j.febslet.2006.03.081

Abstract (EN): Aneuploidy is a common feature of many cancers, suggesting that genomic stability is essential to prevent tumorigenesis. Also, during meiosis, chromosome non-disjunction produces gamete imbalance and when fertilized result in developmental arrest or severe birth defects. The spindle assembly checkpoint prevents chromosome mis-segregation during both mitosis and meiosis. In mitosis, this control system monitors kinetochore-microtubule attachment while in meiosis its role is still unclear. Interestingly, recent data suggest that defects in the spindle assembly checkpoint are unlikely to cause cancer development but might facilitate tumour progression. However, in meiosis a weakened checkpoint could contribute to age-related aneuploidy found in humans.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8