In vivo performance of biodegradable calcium phosphate glass ceramics using the rabbit model: Histological and SEM observation

• Tipo: Artigo em Revista Científica Internacional
• Data: 2006

Autores

Dias, AG (Autor) Outra; Lopes, MA (Autor) FEUP; Santos, JD (Autor) FEUP; Américo Afonso (Autor) FMDUP; Tsuru, K (Autor) Outra; Osaka, A (Autor) Outra; Hayakawa, S (Autor) Outra; Takashima, S (Autor) Outra; Kurabayashi, Y (Autor) Outra

Revista

Título: Journal of Biomaterials Applications

Vol. 20

Páginas: 253-266

ISSN: 0885-3282

Editora: SAGE

Indexação

ISI Web of Knowledge - 19 Citações

Scopus - 23 Citações

Classificação Científica

FOS: Ciências da engenharia e tecnologias > Biotecnologia ambiental

Outras Informações

ID Authenticus: P-004-Q2C

DOI: 10.1177/0885328206052466

Abstract (EN): Two MK5 (45CaO-45P(2)O(5)-5MgO-5K(2)O, in mol%) and MT13 (45CaO-37P(2)O(5)-5MgO-13TiO(2), in mol%) glasses are prepared in the meta- and pyrophosphate regions and crystallized to obtain MK5B and MT13B, respectively. MK5B was obtained by controlled crystallization, and MT13B by powder sintering. As a result of these heat treatment processes, the crystalline phases precipitated in the glassy matrix are KCa(PO3)(3), beta-Ca(PO3)(2), beta-Ca2P2O7 and Ca4P6O19 phases for MK5B and CaTi4(PO4)(6), TiP2O7, alpha- and beta-Ca2P2O7 phases for MT13B. To assess the in vivo biological behavior of these glass ceramics, a mixed granulometry in the range 250-355 mu m and 355-425 mu m with a ratio of 1/1 was implanted for 2, 4, and 12 weeks in the tibiae of Japanese white rabbits. The results showed that the in vivo behavior was strongly affected by their solubility. All implanted materials, MK5B and MT13B, and beta-tricalcium phosphate (beta-TCP) as control material, showed signs of degradation in vivo. However, the levels of degradation were quite different throughout the implantation periods. The highest degradation was observed for MK5B glass ceramic and the lowest for MT13B with beta-TCP in-between. All implanted materials allow for new bone formation in the bone defect area. At the longest implantation period (12 weeks), the MT13B and beta-TCP materials were almost completely surrounded by new bone tissue, whereas MK5B showed some unfilled spaces. This behavior is discussed in terms of the high degradation observed in previous studies.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 14