Changes in LDL size and HDL concentration in normal and preeclamptic pregnancies

• Tipo: Artigo em Revista Científica Internacional
• Data: 2002

Autores

Belo, L (Autor) FFUP; Caslake, M (Autor) Outra; Gaffney, D (Autor) Outra; Santos Silva, A (Autor) FFUP; Pereira Leite, L (Autor) Outra; Quintanilha, A (Autor) ICBAS; Rebelo, I (Autor) FFUP

Revista

Título: Atherosclerosis

Vol. 162

Páginas: 425-432

ISSN: 0021-9150

Editora: Elsevier

Indexação

ISI Web of Knowledge - 108 Citações

Scopus - 120 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina clínica

Outras Informações

ID Authenticus: P-000-P3A

DOI: 10.1016/s0021-9150(01)00734-1

Abstract (EN): The aim of this study was to evaluate changes in lipids. apolipoproteins and lipoproteins in Portuguese pregnant women and their potential involvement in the pathophysiology of preeclampsia. A cross-sectional study was performed by collecting blood samples in the first (n=64), second (n=48) and third (n=67) trimesters and puerperium (n=32) of normal pregnancies. Samples from preeclamptic women were obtained in the third trimester (n=51) and in puerperium (n=26), As normal pregnancy progressed and triglyceride (TG) levels rose there as a decrease in lock density lipoprotein (LDL) size. as measured by peak and mean particle diameter (MPD), with in increased proportion of atherogenic small dense LDL. Preeclamptic women exhibited, in the third trimester and puerperium. higher mean serum TG concentration and lower high density lipoprotein (HDL) cholesterol and apolipoprotein A-I (apo A-I) levels compared with healthy pregnant women. In the third trimester, LDL-mean particle diameter (LDL-MD) and LDL cholesterol-apolipoprotein B (LDLc-apo B) ratio were also significantly reduced in the pathologic group. We Conclude that human gestation is associated with an 'atherogenic' lipid profile that is further enhanced in preeclampsia and that this profile may be a potential contributor to endothelial cell dysfunction.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8