Erythropoiesis versus inflammation in Hereditary Spherocytosis clinical outcome

• Tipo: Artigo em Revista Científica Internacional
• Data: 2011

Autores

Susana Rocha (Autor) FFUP; Elisio Costa (Autor) FFUP; Petronila Rocha Pereira (Autor) Outra; Fatima Ferreira (Autor) Outra; Esmeralda Cleto (Autor) Outra; Jose Barbot (Autor) Outra; Alexandre Quintanilha (Autor) ICBAS; Luis Belo (Autor) FFUP; Alice Santos Silva (Autor) FFUP

Revista

Título: Clinical Biochemistry

Vol. 44

Páginas: 1137-1143

ISSN: 0009-9120

Editora: Elsevier

Indexação

ISI Web of Knowledge - 6 Citações

Scopus - 7 Citações

Classificação Científica

FOS: Ciências da engenharia e tecnologias > Engenharia médica

Outras Informações

ID Authenticus: P-007-ZPG

DOI: 10.1016/j.clinbiochem.2011.06.006

Abstract (EN): Objectives: This study aimed to evaluate the relationship between erythropoiesis and inflammation, in Hereditary Spherocytosis (HS) clinical outcome. Design and methods: We studied 26 controls and 82 HS patients presenting mild (n = 49) and severer (n = 33) HS forms. We evaluated plasma levels of EPO, sTfR, ferritin, iron, folic acid, vitamin B12, TNF-alpha, IFN-gamma, elastase and lactoferrin; leukocyte and reticulocyte counts and RPI were determined. Results: All HS patients showed significantly higher EPO, sTfR, reticulocytes and RPI but only mild HS presented normal hemoglobin levels; the positive significant correlations between EPO and sTfR, reticulocytes and RPI observed in mild HS were not observed in severer HS patients. HS patients presented with higher levels of neutrophils, TNF-alpha, IFN-gamma, elastase, lactoferrin and ferritin. Conclusions: Our data show HS as a disease linked to enhanced erythropoiesis that is disturbed in the more severe forms, to which inflammation may contribute, at least in part.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7