Evaluation of two biodegradable nerve guides for the reconstruction of the rat sciatic nerve

• Tipo: Artigo em Revista Científica Internacional
• Data: 2007

Autores

Ana L Luis (Autor) ICBAS; Jorge M Rodrigues (Autor) FMUP; Jose V Lobato (Autor) Outra; Maria A Lopes (Autor) FEUP; Sandra Amado (Autor) Outra; Antonio P Veloso (Autor) Outra; Paulo A S Armada da Silva (Autor) Outra; Stefania Raimondo (Autor) Outra; Stefano Geuna (Autor) Outra; Antonio J Ferreira (Autor) Outra; Artur S P Varejao (Autor) Outra; Jose D Santos (Autor) FEUP; Ana C Mauricio (Autor) ICBAS

Revista

Título: Bio-Medical Materials and Engineering

Vol. 17

Páginas: 39-52

ISSN: 0959-2989

Editora: IOS PRESS

Indexação

ISI Web of Knowledge - 27 Citações

ISI Web of Science

Scopus - 30 Citações

Classificação Científica

FOS: Ciências da engenharia e tecnologias > Biotecnologia ambiental

CORDIS: Ciências Tecnológicas > Tecnologia > Tecnologia médica > Materiais biomédicos

Outras Informações

ID Authenticus: P-004-CKN

Abstract (EN): The purpose of this study was to test in vivo two different nerve guides, one of PLGA made of a novel proportion (90:10) of the two polymers, Poly(L-lactide):Poly(glycolide), with (DL-lactide-epsilon-caprolactone) copolyester (Neurolac((R))) tube, in promoting nerve regeneration across a 10 mm-gap of the rat sciatic nerve. Finally, end-to-end coaptation was performed. Motor and sensory functional recovery was assessed throughout the healing period of 20 weeks and the repaired nerves were processed for morphological analysis. Both motor and sensory functions improved significantly in all experimental nerve repair groups, although the rate and extent of recovery was significantly higher in the end-to-end group. No significant differences were detected in the comparison between the two types of tubes. Compatible with results of functional tests, morphological analysis showed that axon regeneration occurred in both PLGA and Neurolac((R)) experimental groups but disclosed a different pattern of degradation of the two types of tubes with larger biodegradation of PLGA material by the end of 20 weeks. These results suggest that both types of biomaterial are a good substrate for preparing tubular nerve guides and the different pattern of degradation does not seem to influence the degree of nerve regeneration.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 14