Oxygen and Nitrogen Reactive Species Are Effectively Scavenged by Eucalyptus globulus Leaf Water Extract

• Tipo: Artigo em Revista Científica Internacional
• Data: 2009

Autores

Isabel F Almeida (Autor) FFUP; Eduarda Fernandes (Autor) FFUP; Jose L F C Lima (Autor) FFUP; Patricia Valentao (Autor) FFUP; Paula B Andrade (Autor) FFUP; Rosa M Seabra (Autor) Outra; Costa, PC (Autor) FFUP; Bahia, MF (Autor) Outra

Revista

Título: Journal of Medicinal Food

Vol. 12 Nº 1

Páginas: 175-183

ISSN: 1096-620X

Editora: Mary Ann Liebert

Indexação

ISI Web of Knowledge - 33 Citações

Scopus - 36 Citações

Classificação Científica

FOS: Ciências agrárias > Outras ciências agrárias

Outras Informações

ID Authenticus: P-003-NHV

DOI: 10.1089/jmf.2008.0046

Abstract (EN): Eucalyptus globulus Labill. (Family Myrtaceae) is a plant of Australian origin, with a reported therapeutic use in airway inflammatory diseases. Considering that reactive oxygen species (ROS) and reactive nitrogen species (RNS) have been implicated in the pathogenesis of airway inflammatory diseases such as asthma and chronic obstructive pulmonary disease, an effective scavenging activity against these reactive species may contribute for the therapeutic effect of this plant. In the present study, a water extract of E. globulus leaves was evaluated for its putative in vitro scavenging effects on ROS (HO(center dot), O(2)(center dot-), ROO(center dot), and H(2)O(2)) and RNS ((center dot)NO and ONOO(-)) and on 2,2-diphenyl-1-picrylhydrazyl radical (DPPH). Qualitative and quantitative analyses of the extract's phenolic composition were also performed. The Eucalyptus leaf water extract presented a remarkable capacity to scavenge all the reactive species tested, with all the 50% inhibitory concentrations being found at the mu g/mL level. Phytochemical analysis showed the presence of polyphenols such as flavonoids (rutin and quercitrin) and phenolic acids (chlorogenic acid and ellagic acid), which may be partially responsible for the observed antioxidant activity. These observations provide further support, beyond the well-known antibacterial and antiviral activities of the Eucalyptus plant, for its reported use in traditional medicine such as in the treatment of airway inflammatory diseases, considering the important role of ROS and RNS in the inflammatory process, although further studies are needed to prove the bioavailability of the antioxidants/antibacterial compounds of the extract as well as the ability of the active compounds to reach specific tissues and to act in them.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9