Alzheimer's Disease, Cholesterol, and Statins: The Junctions of Important Metabolic Pathways

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2013

Autores

Tiago Silva (Autor) Outra; Jose Teixeira (Autor) Outra; Fernando Remiao (Autor) FFUP; Fernanda Borges (Autor) FCUP

Revista

Título: Angewandte Chemie - International Edition

Vol. 52

Páginas: 1110-1121

ISSN: 1433-7851

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 51 Citações

Scopus - 52 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Química

CORDIS: Ciências Físicas > Química > Química aplicada > Química farmacêutica

Outras Informações

ID Authenticus: P-002-1R6

DOI: 10.1002/anie.201204964

Abstract (EN): Recent years have seen a significant increase in published data supporting the positive effects of statins on neurodegenerative diseases, in particular on Alzheimers disease. Statins show neuroprotective activity by a combination of different cellular and systemic mechanisms that are based on the inhibition of the biosynthesis of cholesterol and isoprenoid by-products. The promising results obtained in vivo and in epidemiological studies are generally not in accordance with those of placebo-controlled randomized clinical trials. Nevertheless, these results make statins valuable assets for disease prevention rather than therapeutic agents for use when disease symptoms are already displayed. Thus, the modulation of midlife cholesterol and/or statin administration prior to the appearance of dementia or cognitive impairment may have a better long-term outcome.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 12