Abstract (EN):
Bone tissue engineering is a very challenging and promising field, which handles with
the limitations of bone regenerative capacity and the failure of current orthopedic
implants [1].
This work describes the preparation and characterization of an injectable dextrinbased
hydrogel (oDex) through dextrin oxidation followed by cross-linking with a
dihydrazide [2]. In vitro and in vivo experiments allowed to conclude that this system
can carry and stabilize cells, nanogels, Bonelike® granules [3] and other biomolecules.
This is a promising biomaterial due to its biocompatibility, and potential to promote an
adequate environment for bone regeneration, which was increased by the combined
bioactive molecules. Its injectability allows a minimal invasive surgical procedure with
decreased patient morbidity, lower infection risk and reduced scar formation.
Furthermore, an adequate sterilization protocol for this kind of material was
established.
The tight collaboration between University of Minho and Bioskin S.A. company,
envisioning technology transfer and product valorization, has resulted in a published
international patent of the product (WO2011070529A2) [4]. Currently, the submission
of a request for the authorization for the clinical trials is being planned.
Idioma:
Inglês
Tipo (Avaliação Docente):
Científica
Nº de páginas:
1
Tipo de Licença: