Natural Ergot Alkaloids in Ocular Pharmacotherapy: Known Molecules for Novel Nanoparticle-Based Delivery Systems

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2020

Autores

Baldim, I (Autor) Outra; Oliveira, WP (Autor) Outra; Kadian, V (Autor) Outra; Rao, R (Autor) Outra; Yadav, N (Autor) Outra; Mahant, S (Autor) Outra; Lucarini, M (Autor) Outra; Durazzo, A (Autor) Outra; Da Ana, R (Autor) Outra; Capasso, R (Autor) Outra; Souto, SB (Autor) FMUP; Santini, A (Autor) Outra; Souto, EB (Autor) Outra

Revista

Título: Biomolecules

Vol. 10

Páginas: 1-21

ISSN: 2218-273X

Editora: MDPI

Indexação

ISI Web of Knowledge - 6 Citações

Scopus - 7 Citações

Classificação Científica

CORDIS: Ciências da Saúde

Outras Informações

ID Authenticus: P-00S-DAR

DOI: 10.3390/biom10070980

Abstract (EN): Several pharmacological properties are attributed to ergot alkaloids as a result of their antibacterial, antiproliferative, and antioxidant effects. Although known for their biomedical applications (e.g., for the treatment of glaucoma), most ergot alkaloids exhibit high toxicological risk and may even be lethal to humans and animals. Their pharmacological profile results from the structural similarity between lysergic acid-derived compounds and noradrenalin, dopamine, and serotonin neurotransmitters. To reduce their toxicological risk, while increasing their bioavailability, improved delivery systems were proposed. This review discusses the safety aspects of using ergot alkaloids in ocular pharmacology and proposes the development of lipid and polymeric nanoparticles for the topical administration of these drugs to enhance their therapeutic efficacy for the treatment of glaucoma.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 20