The action of phytochemicals in biofilm control

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2022

Autores

Gonçalves, ASC (Autor) Outra; Leitão, MM (Autor) Outra; Simões, M (Autor) Outra; Anabela Borges (Autor) FEUP; Simões M (Autor) FEUP

Revista

Título: Natural Product Reports

Vol. 40 Nº 3

Páginas: 595-627

ISSN: 0265-0568

Editora: Royal Society of Chemistry

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 2 Citações

Projetos Associados

ALiCE - ALiCE - Laboratório Associado em Engenharia Química

LEPABE - Financiamento Plurianual 2020-2023 da Unidade de I&D LEPABE - Laboratório de Engenharia de Processos, Ambiente, Biotecnologia e Energia

Biocide_for_Biofilm - Desenvolvimento de novas soluções biocidas para o controlo efetivo de biofilmes

GermIrrad - Sistema automatizado de irradiação germicida

Outras Informações

ID Authenticus: P-00X-KPZ

DOI: 10.1039/d2np00053a

Abstract (EN): Covering: 2009 to 2021 Antimicrobial resistance is now rising to dangerously high levels in all parts of the world, threatening the treatment of an ever-increasing range of infectious diseases. This has becoming a serious public health problem, especially due to the emergence of multidrug-resistance among clinically important bacterial species and their ability to form biofilms. In addition, current anti-infective therapies have low efficacy in the treatment of biofilm-related infections, leading to recurrence, chronicity, and increased morbidity and mortality. Therefore, it is necessary to search for innovative strategies/antibacterial agents capable of overcoming the limitations of conventional antibiotics. Natural compounds, in particular those obtained from plants, have been exhibiting promising properties in this field. Plant secondary metabolites (phytochemicals) can act as antibiofilm agents through different mechanisms of action from the available antibiotics (inhibition of quorum-sensing, motility, adhesion, and reactive oxygen species production, among others). The combination of different phytochemicals and antibiotics have revealed synergistic or additive effects in biofilm control. This review aims to bring together the most relevant reports on the antibiofilm properties of phytochemicals, as well as insights into their structure and mechanistic action against bacterial pathogens, spanning December 2008 to December 2021.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 32