Surface activation of medical grade polyurethane for the covalent immobilization of an anti-adhesive biopolymeric coating

• Tipo: Artigo em Revista Científica Internacional
• Data: 2021

Autores

Jorge Matinha Cardoso (Autor) Outra; Rita Mota (Autor) Outra; Luciana Gomes (Autor) FEUP; Filipe Mergulhão (Autor) FEUP; Paula Tamagnini (Autor) FCUP; M. Cristina L. Martins (Autor) Outra; Fabíola Costa (Autor) Outra

Revista

Título: Journal of Materials Chemistry B

Vol. 9

Páginas: 3705-3715

ISSN: 2050-7518

Editora: Royal Society of Chemistry

Indexação

ISI Web of Knowledge - 6 Citações

Scopus - 7 Citações

Outras Informações

ID Authenticus: P-00T-W21

DOI: 10.1039/d1tb00278c

Abstract (EN): Hospital-acquired infections are still a major concern worldwide, being frequently related to bacterial biofilm formation on medical devices, and thus difficult to eradicate with conventional antimicrobial treatments. Therefore, infection-preventive solutions based on natural polymers are being investigated. Recently, a marine cyanobacterium-derived polymeric coating (CyanoCoating) has demonstrated great anti-adhesive potential when immobilized onto gold model substrates. In this work, we took this technology a step closer to an industrial application by covalently immobilizing CyanoCoating onto medical grade polyurethane (PU). This immobilization was developed through the introduction of linkable moieties onto a PU inert surface using different pre-treatments. Besides the application of the polydopamine (pDA) linker layer, other processes frequently found in industrial settings, such as atmospheric plasma (using O-2 or N-2 as reactive gases) and ozone surface activations, were evaluated. From all the pre-treatments tested, the ozone activation was the most promising since the obtained coating not only revealed a homogeneous distribution, but also significantly reduced the adhesion of two relevant etiological bacteria in static conditions (the Gram-positive Staphylococcus aureus and the Gram-negative Escherichia coli). Moreover, it also impaired E. coli biofilm formation under simulated urinary tract dynamic conditions, reinforcing the potential of CyanoCoating as an antibiotic-free alternative to mitigate medical device-associated infections, particularly in the urinary tract.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 11