Translating endoplasmic reticulum biology into the clinic: a role for ER-targeted natural products?

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2015

Autores

David M Pereira (Autor) FFUP; Patricia Valentao (Autor) Outra; Georgina Correia da Silva (Autor) FFUP; Natercia Teixeira (Autor) FFUP; Paula B Andrade (Autor) FFUP

Revista

Título: Natural Product Reports

Vol. 32

Páginas: 705-722

ISSN: 0265-0568

Editora: Royal Society of Chemistry

Indexação

ISI Web of Knowledge - 15 Citações

Scopus - 20 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Química

Outras Informações

ID Authenticus: P-00A-DC2

DOI: 10.1039/c4np00102h

Abstract (EN): ER stress has been identified as a hallmark, and sometimes trigger, of several pathologies, notably cancer, inflammation and neurodegenerative diseases like Alzheimer's and Parkinson's. Among the molecules described in literature known to affect ER function, the majority are natural products, suggesting that natural molecules may constitute a significant arsenal of chemical entities for modulating this cellular target. In this review, we will start by presenting the current knowledge of ER biology and the hallmarks of ER stress, thus paving the way for presenting the natural products that have been described as being ER modulators, either stress inducers or ER protectors. The chemistry, distribution and mechanism of action of these compounds will be presented and discussed.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 18