Multi-pumping flow system for the spectrophotometric determination of dipyrone in pharmaceutical preparations

• Tipo: Artigo em Revista Científica Internacional
• Data: 2003

Autores

Lima, JLFC (Autor) FFUP; Sa, SMO (Autor) Outra; Santos, JLM (Autor) FFUP; Zagatto, EAG (Autor) Outra

Revista

Título: Journal of Pharmaceutical and Biomedical Analysis

Vol. 32 Nº 4

Páginas: 1011-1017

ISSN: 0731-7085

Editora: Elsevier

Indexação

ISI Web of Knowledge - 30 Citações

ISI Web of Science

Scopus - 31 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Química

CORDIS: Ciências da Saúde

Outras Informações

ID Authenticus: P-000-FJY

DOI: 10.1016/s0731-7085(03)00203-6

Resumo (PT): A novel flow system for the spectrophotometric determination of dipyrone with p-dimethylaminobenzaldehyde exploiting the multi-pumping approach was developed. The proposed methodology utilises several micro-pumps for propelling the involved fluids under improved mixing conditions, introducing sample/reagent aliquots and providing commuting facilities. As a consequence the multi-pumping system presents high versatility and manifold simplicity, as well as a straightforward operational control and enhanced analytical capabilities. Linearity of the analytical curve was observed within 10 and 400 mg l−1 dipyrone (r=0.9997; n=6), results were precise (r.s.d.<0.12%; n=20) and sampling rate was 50 h−1. Detection limit was estimated as 1 mg l−1 dipyrone. The method was applied to pharmaceutical preparations and the results were in agreement with those obtained by the reference procedure with relative deviations within −1.7 and +2.2%. <br> <br> Keywords: Flow analysis; Multi-pumping flow system; Dipyrone; Spectrophotometry; p-dimethylaminobenzaldehyde; Pharmaceutical preparations <br> <a href="http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TGX-48PM5N0-8&_user=2460038&_coverDate=08%2F08%2F2003&_rdoc=44&_fmt=high&_orig=browse&_srch=doc-info(%23toc%235266%232003%23999679995%23442578%23FLA%23display%23Volume)&_cdi=5266&_sort=d&_docanchor=&_ct=56&_acct=C000057398&_version=1&_urlVersion=0&_userid=2460038&md5=2029871211816a7eea9b052cbad0ace8"> Texto integral</a> <br> <br>

Abstract (EN): A novel flow system for the spectrophotometric determination of dipyrone with p-dimethylaminobenzaldehyde exploiting the multi-pumping approach was developed. The proposed methodology utilises several micro-pumps for propelling the involved fluids under improved mixing conditions, introducing sample/reagent aliquots and providing commuting facilities. As a consequence the multi-pumping system presents high versatility and manifold simplicity, as well as a straightforward operational control and enhanced analytical capabilities. Linearity of the analytical curve was observed within 10 and 400 mg l(-1) dipyrone (r = 0.9997; n = 6), results were precise (r.s.d. < 0.12%; n = 20) and sampling rate was 50 h(-1). Detection limit was estimated as 1 mg l(-1) dipyrone. The method was applied to pharmaceutical preparations and the results were in agreement with those obtained by the reference procedure with relative deviations within -1.7 and +2.2%.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7