The antiviral activity of rodent and lagomorph SERINC3 and SERINC5 is counteracted by known viral antagonists

• Tipo: Artigo em Revista Científica Internacional
• Data: 2019

Autores

de Sousa Pereira, P (Autor) Outra; Abrantes, J (Autor) FCUP; Bauernfried, S (Autor) Outra; Pierini, V (Autor) Outra; Esteves, PJ (Autor) FCUP; Keppler, OT (Autor) Outra; Pizzato, M (Autor) Outra; Hornung, V (Autor) Outra; Fackler, OT (Autor) Outra; Baldauf, HM (Autor) Outra

Revista

Título: Journal of General Virology

Vol. 100

Páginas: 278-288

ISSN: 0022-1317

Editora: Microbiology Society

Indexação

ISI Web of Knowledge - 13 Citações

Scopus - 13 Citações

Outras Informações

ID Authenticus: P-00Q-6FM

DOI: 10.1099/jgv.0.001201

Abstract (EN): A first step towards the development of a human immunodeficiency virus (HIV) animal model has been the identification and surmounting of species-specific barriers encountered by HIV along its replication cycle in cells from small animals. Serine incorporator proteins 3 (SERINC3) and 5 (SERINC5) were recently identified as restriction factors that reduce HIV-1 infectivity. Here, we compared the antiviral activity of SERINC3 and SERINC5 among mice, rats and rabbits, and their susceptibility to viral counteraction to their human counterparts. In the absence of viral antagonists, rodent and lagomorph SERINC3 and SERINC5 displayed anti-HIV activity in a similar range to human controls. Vesicular stomatitis virus G protein (VSV-G) pseudotyped virions were considerably less sensitive to restriction by all SERINC3/5 orthologs. Interestingly, HIV-1 Nef, murine leukemia virus (MLV) GlycoGag and equine infectious anemia virus (EIAV) S2 counteracted the antiviral activity of all SERINC3/5 orthologs with similar efficiency. Our results demonstrate that the antiviral activity of SERINC3/5 proteins is conserved in rodents and rabbits, and can be overcome by all three previously reported viral antagonists.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 11