Suicidal ideation in a European Huntington's disease population

• Tipo: Artigo em Revista Científica Internacional
• Data: 2013

Autores

Hubers, AAM (Autor) Outra; van Duijn, E (Autor) Outra; Roos, RAC (Autor) Outra; Craufurd, D (Autor) Outra; Rickards, H (Autor) Outra; Landwehrmeyer, GB (Autor) Outra; van der Mast, RC (Autor) Outra; Giltay, EJ (Autor) Outra; João Massano (Autor) FMUP

Revista

Título: Journal of Affective Disorders

Vol. 151

Páginas: 248-258

ISSN: 0165-0327

Editora: Elsevier

Indexação

ISI Web of Knowledge - 54 Citações

Scopus - 62 Citações

Outras Informações

ID Authenticus: P-00G-931

DOI: 10.1016/j.jad.2013.06.001

Abstract (EN): Background: Previous studies indicate increased prevalences of suicidal ideation, suicide attempts, and completed suicide in Huntington's disease (HD) compared with the general population. This study investigates correlates and predictors of suicidal ideation in HD. Methods: The study cohort consisted of 2106 HD mutation carriers, all participating in the REGISTRY study of the European Huntington's Disease Network. Of the 1937 participants without suicidal ideation at baseline, 945 had one or more follow-up measurements. Participants were assessed for suicidal ideation by the behavioural subscale of the Unified Huntington's Disease Rating Scale (UHDRS). Correlates of suicidal ideation were analyzed using logistic regression analysis and predictors were analyzed using Cox regression analysis. Results: At baseline, 169 (8.0%) mutation carriers endorsed suicidal ideation. Disease duration (odds ratio [OR]=0.96; 95% confidence interval [CI]: 0.9-1.0), anxiety (OR=2.14; 95%CI: 1.4-3.3), aggression (OR=2.41; 95%CI: 1.5-3.8), a previous suicide attempt (OR=3.95; 95%CI: 2.4-6.6), and a depressed mood (OR=13.71; 95%CI: 6.7-28.0) were independently correlated to suicidal ideation at baseline. The 4-year cumulative incidence of suicidal ideation was 9.9%. Longitudinally, the presence of a depressed mood (hazard ratio [HR]=2.05; 95%CI: 1.1-4.0) and use of benzodiazepines (HR=2.44; 95%CI: 1.2-5.0) at baseline were independent predictors of incident suicidal ideation, whereas a previous suicide attempt was not predictive. Limitations: As suicidal ideation was assessed by only one item, and participants were a selection of all HD mutation carriers, the prevalence of suicidal ideation was likely underestimated. Conclusions: Suicidal ideation in HD frequently occurs. Assessment of suicidal ideation is a priority in mutation carriers with a depressed mood and in those using benzodiazepines.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 11