Beyond the beaten path: improving natural products bioprospecting using an eco-evolutionary framework - the case of the octocorals

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2018

Autores

Ledoux, JB (Autor) Outra; Agostinho Antunes (Autor) FCUP

Revista

Título: Critical Reviews in Biotechnology

Vol. 38

Páginas: 184-198

ISSN: 0738-8551

Editora: Taylor & Francis

Indexação

ISI Web of Knowledge - 8 Citações

Scopus - 8 Citações

Outras Informações

ID Authenticus: P-00N-SEF

DOI: 10.1080/07388551.2017.1331335

Abstract (EN): Marine natural products (NPs) represent an impressive source of novel bioactive molecules with major biotechnological applications. Nevertheless, the usual chemical and applied perspective leading most of bioprospecting projects come along with various limitations blurring our understanding of the extensive marine chemical diversity. Here, we propose several guidelines: (i) to optimize bioprospecting and (ii) to refine our knowledge on marine chemical ecology focusing on octocorals, one of the most promising sources of marine NPs. We identified a significant phylogenetic bias in the octocoral bioprospecting, which calls for the development of a concerted discovery strategy. Given the gap existing between the number of isolated NPs and the knowledge regarding their functions, we provide an ecologically centered workflow prioritizing biological function ahead of chemical identification. Furthermore, we illustrate how -omic technologies should rapidly increase our knowledge on solving different aspects of the ecology and evolution of marine NPs.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 15