Longer duration of obesity is associated with a reduction in urinary angiotensinogen in prepubertal children

• Tipo: Artigo em Revista Científica Internacional
• Data: 2017

Autores

Morato, M (Autor) FFUP; Correia Costa, L (Autor) Outra; Sousa, T (Autor) FMUP; Cosme, D (Autor) Outra; Schaefer, F (Autor) Outra; Areias JC (Autor) FMUP; Antonio Guerra (Autor) FMUP; Alberto Caldas Afonso (Autor) ICBAS; Barros H (Autor) FMUP; Azevedo A (Autor) FMUP; Albino Teixeira, A (Autor) FMUP

Revista

Título: Pediatric Nephrology

Vol. 32

Páginas: 1411-1422

ISSN: 0931-041X

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 3 Citações

Scopus - 3 Citações

Outras Informações

ID Authenticus: P-00M-KT7

DOI: 10.1007/s00467-017-3639-y

Abstract (EN): We aimed to study the impact of obesity on urinary excretion of angiotensinogen (U-AGT) in prepubertal children, focusing on the duration of obesity and gender. Also, we aimed to evaluate whether plasma angiotensinogen (P-AGT) and hydrogen peroxide (H2O2) play a role in the putative association. Cross-sectional evaluation of 305 children aged 8-9 years (160 normal weight, 86 overweight, and 59 obese). Anthropometric measurements and 24-h ambulatory blood pressure monitoring were performed. Angiotensinogen (AGT) was determined by a commercial enzyme-linked immunosorbent assay (ELISA) kit and H2O2 by a microplate fluorometric assay. U-AGT and P-AGT levels were similar across body mass index (BMI) groups and between sexes. However, boys who were overweight/obese since the age of 4 years presented lower levels of U-AGT compared with those of normal weight at the same age. In children who were overweight/obese since the age of 4, urinary H2O2 decreased with P-AGT. A higher duration of obesity was associated with decreased U-AGT in boys, thus reflecting decreased intrarenal activity of the renin-angiotensin system. Also, children with a longer duration of obesity showed an inverse association between urinary H2O2 and P-AGT. Future studies should address whether these results reflect an early compensatory mechanism to limit obesity-triggered renal dysfunction.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 12