Expression of E-cadherin, P-cadherin and beta-catenin in canine malignant mammary tumours in relation to clinicopathological parameters, proliferation and survival

• Tipo: Artigo em Revista Científica Internacional
• Data: 2008

Autores

Gama, A (Autor) Outra; Joana Paredes (Autor) FMUP; Fátima Gärtner (Autor) ICBAS; Alves, A (Autor) Outra; Fernando Schmitt (Autor) FMUP

Revista

Título: Veterinary Journal

Vol. 177

Páginas: 45-53

ISSN: 1090-0233

Editora: Elsevier

Indexação

ISI Web of Knowledge - 58 Citações

Scopus - 66 Citações

Outras Informações

ID Authenticus: P-003-YDY

DOI: 10.1016/j.tvjl.2007.05.024

Abstract (EN): Cadherin-catenin complexes play a critical role in intercellular adhesion, and their altered expression has been implicated in tumour progression. In this study, the expression of E-cadherin, P-cadherin and beta-catenin was analysed in 65 canine malignant mammary tumours and correlated with clinicopathological parameters, proliferation and survival. Reduction in E-cadherin expression was significantly associated with increased tumour size, high histological and invasion grades, lymph node metastasis and high mitotic index. Reduced beta-catenin expression was associated with high histological and invasion grades. Anomalous expression of P-cadherin was only associated with invasion. In 39 cases for which follow-up data were available, reduced E-cadherin and beta-catenin expression was significantly associated with shorter overall survival and disease free survival. Abnormal expression of adhesion molecules is a common phenomenon in canine mammary malignant tumours and may play a central role in tumour progression.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9