The role of adipocytes in the modulation of iron metabolism in obesity

• Tipo: Artigo em Revista Científica Internacional
• Data: 2013

Autores

Coimbra, S (Autor) Outra; Catarino, C (Autor) FFUP; Santos Silva, A (Autor) FFUP

Revista

Título: Obesity Reviews

Vol. 14

Páginas: 771-779

ISSN: 1467-7881

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 31 Citações

Scopus - 37 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina clínica

Outras Informações

ID Authenticus: P-006-6RS

DOI: 10.1111/obr.12057

Abstract (EN): A tight relationship between iron deficiency and obesity is known to exist. The chronic low-grade inflammation that characterizes obesity enhances hepcidin production, the principal regulator of iron availability. Adipose tissue is known to secret interleukin-6 and leptin that triggers hepcidin production. It was found that adipose tissue also expresses hepcidin and hemojuvelin, a regulator of hepcidin production. These recent findings suggest that adipose tissue may have an important role in erythropoiesis particularly on obesity that is still poorly clarified. This paper discusses these findings and how they can modulate erythropoiesis.

Idioma: Inglês

Tipo (Avaliação Docente): Científica