Adiponectin is an independent predictor of tissue plasminogen activator levels in patients under haemodialysis

• Tipo: Artigo em Revista Científica Internacional
• Data: 2012

Autores

Maria do Sameiro Faria (Autor) Outra; Sandra Ribeiro (Autor) Outra; Henrique Nascimento (Autor) Outra; Petronila Rocha Pereira (Autor) Outra; Vasco Miranda (Autor) Outra; Denisa Mendonca (Autor) ICBAS; Alexandre Quintanilha (Autor) ICBAS; Elisio Costa (Autor) FFUP; Luis Belo (Autor) FFUP; Alice Santos Silva (Autor) FFUP

Revista

Título: Scandinavian Journal of Urology and Nephrology

Vol. 46

Páginas: 461-465

ISSN: 0036-5599

Editora: Taylor & Francis

Indexação

ISI Web of Knowledge - 1 Citação

Scopus - 1 Citação

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina clínica

Outras Informações

ID Authenticus: P-002-2YX

DOI: 10.3109/00365599.2012.708943

Abstract (EN): Objective. The aim of this study was to evaluate the association of tissue-type plasminogen activator (t-PA) levels with clinical data of patients under haemodialysis (HD) and with several variables potentially related to endothelial function and dysfunction. Material and methods. In a cross-sectional study involving 189 Portuguese HD patients, circulating levels of t-PA, lipids, oxidized low-density lipoprotein (Ox-LDL), interleukin-6 (IL-6), C-reactive protein (CRP), adiponectin, plasminogen activator inhibitor type 1 (PAI-1) and fibrin fragment D-dimer were measured. Results. Considering the entire population, t-PA correlated inversely and significantly with adiponectin and high-density lipoprotein-cholesterol, and positively and significantly with age, body mass index, PAI-1, IL-6, CRP, D-dimer, cholesterol and Ox-LDL. In multiple linear regression analysis PAI-1, age and adiponectin remained statistically associated with t-PA values (p < 0.01 for all). The weakest significant association (p = 0.046) was that found between t-PA and D-dimer. Conclusion. Adiponectin is a main determinant of t-PA level, which may be a good marker of endothelial dysfunction in HD patients.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5