Clinical Biochemistry
| Code: | MI074235 | Acronym: | BIOQCL |
| Keywords | |
|---|---|
| Classification | Keyword |
| OFICIAL | Health Sciences |
Instance: 2021/2022 - 2S 
| Active? | Yes |
| Web Page: | http://moodle.up.pt/course/view.php?id=3748 |
| Responsible unit: | Biochemistry Laboratory |
| Course/CS Responsible: | MSc in Pharmaceutical Sciences |
Cycles of Study/Courses
| Acronym | No. of Students | Study Plan | Curricular Years | Credits UCN | Credits ECTS | Contact hours | Total Time |
|---|---|---|---|---|---|---|---|
| MICF | 212 | Official Curriculum | 4 | - | 6 | 52 | 162 |
Teaching language
PortugueseObs.: Português - Suitable for English-speaking students Obs.: Atendimento em inglês aos estudantes; materiais de estudo em inglês; avaliação em inglês (Assistance in English to students; English study materials; English assessment)
Objectives
The theoretical programme aims to give a theoretical elementary training in the area of Clinical Biochemistry, the chemical and biochemical methods applied to the study of different pathologies, the related molecular mechanisms as well as the interpretation of analytical results in relation to diagnosis and treatment of diseases. In the laboratory programme, in parallel with the theoretical programme, it is emphasised the importance of a correct collection of samples, the interpretation and execution of a basic clinical biochemical laboratory study, as well as the correlation between the analytical results and the diagnostic and treatment of diseases.
Learning outcomes and competences
Counselling for a correct sample collection. Execution and understanding of a basic clinical biochemical laboratory study. Interpretation of analytical results in relation to diagnosis monitoring and treatment.
Contribution of learning outcomes to the objectives of MICF
Contribution to the Pharmaceutical Act:
Interpretation and evaluation of medical prescriptions; Execution, interpretation and validation of clinical analyses;
Contribution to the competencies defined in the document “FIP Global Competency Framework”:
1.1 Emergency response
1.1.1 Participate in responding to public health emergencies
1.2 Health promotion
2.6 Patient diagnosis and counseling
2.6.4 Assess, validate and produce health education information, health care advice
4.1 Communication skills
Working method
PresencialPre-requirements (prior knowledge) and co-requirements (common knowledge)
Previous knowledge of basic biochemistry, immunology and physiology.
Program
Function of clinical chemistry. Use of biochemical tests in the diagnosis, monitoring and screening of diseases. Samples used in clinical analysis. Interpretation of laboratory results. Administrative and analytical errors. Biochemical tests conducted outside the clinical laboratory: analytical and interpretative problems. Quality control. Reference values and biological and analytical variability. Glucose homeostasis. Insulin receptor and signaling pathways. Metabolic syndrome. Diabetes. Diagnosis and classification: type 1, type 2, other types, Gestational diabetes. Lipids. Pathological alterations in the metabolism of lipoproteins and their treatment. Risk factors in the development of cardiovascular diseases. Proteins and electrophoretic patterns. Enzymes in clinical pathology. Biochemical markers of acute stroke. Kidney physiology, diseases and kidney function tests. Chemical and cytologic urinalysis. Non-protein nitrogen compounds. Uric acid and gout. Liver function, hepatic diseases and function tests. Endocrinology of thyroid and hormonal determinations. Bone metabolism and bone turnover markers. Serum tumor markers. Pregnancy and evaluation of biochemical foetal well-being tests.
Mandatory literature
Gaw Allan 070; Clinical biochemistry. ISBN: 0-443-07269-8Burtis Carl A. ed.; Tietz textbook of clinical chemistry. ISBN: 0-7216-5610-2
Marshall, William J.; Clinical chemistry. ISBN: 0-7234-3159-0
Comments from the literature
Videos and scientific articles and "Case Reports" will available on the Moodle platform.
Teaching methods and learning activities
Theoretical Classes: 2 hours/week . Magisterial classes with data show; Moodle platform. Laboratory classes: 2 hours/week . During the 2-hour laboratory class the students work individually or in pairs and in the end present a report and discuss the results. Presentation and discussion of case studies and scientific searchs in PubMed. Students receive support material and protocols at the beginning of the period.
Evaluation Type
Distributed evaluation without final examAssessment Components
| designation | Weight (%) |
|---|---|
| Exame | 80,00 |
| Trabalho laboratorial | 20,00 |
| Total: | 100,00 |
Amount of time allocated to each course unit
| designation | Time (hours) |
|---|---|
| Frequência das aulas | 200,00 |
| Trabalho laboratorial | 2,00 |
| Total: | 202,00 |
Eligibility for exams
Attendance to laboratory classes is mandatory. Those students whose attendance is lower than 75% of the foreseen classes are considered as without attendance.
Calculation formula of final grade
The classification is according to the rules in FFUP.
The theoretical evaluation will be distributed, without final exam (two tests). The student must have at least 9.5 out of 20 to be approved.
The laboratorial evaluation consists of a) discussion of case studies (1 out of 20); b) lab. exam that takes place in the last laboratorial class and include any of the assays performed along the laboratorial classes (3 out of 20). This exam is mandatory. The student must have at least 9.5 out of 20 to be approved.
The final mark will be calculated according to:
80% of the theoretical component + 20% of the mark from the laboratorial component
Global classification of the Unit is provided by: 80% of the theoretical evaluation + 20% of the laboratory evaluation.
Special assessment (TE, DA, ...)
The evaluation is made in accordance with the current, existing norms in the Faculty of Pharmacy, University of Porto.
Classification improvement
The student has the right to request to repeat the theoretical component only once either in the normal or in the resit exam calendar following the period in which the approval was obtained. The higher mark obtained, will be considered for the evaluation of the final mark in the Unit. The final mark will be provided by the higher mark in the final written exam and the laboratory mark obtained in the laboratory exam.
Observations
Previously knowledge in basic biochemistry is required including biomolecules and metabolism. Knowledge of Cell Biology, Biochemistry, Immunology and Physiology. Basic knowledge of statistics. Teaching Language: Portuguese and English.
Theoretical classes as well as laboratory protocols are available in English.
Mobility Students
In addition to students who can quickly develop
Portuguese comprehension skills (namely Spanish
and Italian), Mobility Students with fluency in English
are accepted.
The UC is taught in Portuguese, however, the teachers
provide bibliography and support in English. In addition,
the Mobility Students assessment processes can be,
if requested, in English.
Changes arising from the Covid-19 Contingency Plan
Scenario of limitation in the capacity of rooms and
laboratories for face-to-face classes
The schedule for classes and assessments is
adjusted according to the situation at the moment and
made available in Moodle
- Changes to “Objectives”, “Learning Outcomes and Skills” and “program”:
- Without substantial changes
- Changes to “Teaching methods and learning activities”:
- Theoretical classes will be face to face to the limit of the capacity of the amphitheater (with synchronous videoconference (according to the technical facilities available), at the established times. It will be used platforms such as Colibri-Zoom and Panopto for students who do not have access to the amphitheater;
- The laboratory classes take place in the laboratories, respecting 50% of the usual capacity, with the division of the class in even and odd shifts.
- The explanation classes of laboratory work will be pre-recorded and made available (prior to the respective laboratory classes). Students who are on the shift that is not in laboratory class will have self-knowledge tests/individual works (in Moodle) on the same topics.
- Changes in “Type of Assessment”, “Assessment Component”, “Occupation Component”; Frequency Obtaining ”; “Formula for calculating the final classification” and “Classification Improvement”:
- Without substantial changes, however, some evaluation processes may take place at distance
Scenario of all classes taking place at a distance
The schedule for classes and distributed assessment is adjusted and made available at Moodle.
- Changes to “Objectives”, “Learning Outcomes and Skills” and “program”:
- Without changes. However, the absence of the laboratory component partially compromises the described objective of developing methodological skills and the learning result associated with the interpretation of experimental data and clinical analysis.
- Changes to “Teaching methods and learning activities”:
- Theoretical classes will be taught in synchronous videoconference, at the established times and using platforms such as Colibri-Zoom and Panopto;
- Laboratory classes are taught in synchronous sessions in which laboratory protocols are presented and discussed, as well as the expected experimental results.
- Changes in “Type of Assessment”, “Assessment Component”, “Occupation Component”; Frequency Obtaining ”; “Formula for calculating the final classification” and “Classification Improvement”:
- Without substantial changes, however, some evaluation processes must take place at distance
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