Haematology

Code:

MI074133

Acronym:

HEMATO

Keywords
Classification	Keyword
OFICIAL	Health Sciences

Instance: 2021/2022 - 1S

Active?	Yes
Responsible unit:	Biochemistry Laboratory
Course/CS Responsible:	MSc in Pharmaceutical Sciences

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MICF	219	Official Curriculum	4	-	6	52	162

Teaching language

Portuguese

Objectives

 

The aim of the teoric component of these studies is to prepare the students with a solid basis in hematology, giving a particular emphasis in the most prevalent hematologic disorders in Portugal. The laboratorial component, strongly linked to the teoric component, prepares the student to  perform the hematological studies needed to the first aproach to an hematological patient and to its correct reading and interpretation. It is important for a pharmacist the knowledge of the medicines used in hematological disorders and the laboratorial assays used for their diagnosis and monitoring.

 

Learning outcomes and competences

 

The teoric componente of this curricular unit aims to endow students with hematologic,   biochemical, physiological, immunological and genetic knowledge to understand the mechanisms involved in blood cell production, in the development of erythrocyte pathologies, hemostatic disturbances, hematologic malignancies and, also, to the blood groups. This knowledge will enable the student for a better understanding of the clinical and laboratorial findings, crucial for the diagnosis and prognosis of these pathologies. Alongside, in the laboratorial component, the student will perform hematologic studies, usually used for the diagnosis of hematologic disorders. The presentation and discussion of clinical cases to illustrate the pathologies under study, will contribute to a better linkage between teoric and laboratorial knowledge and also to develop student skills for resolution and analysis of the studies of a patient with an hematologic pathology.

 

Working method

Presencial

Pre-requirements (prior knowledge) and co-requirements (common knowledge)

Previous knowledge in biology. biochemistry, physiology, immunology and genetic are be importamt for a better understnding of the program content.

Program

 

Teoric program:

Hematopoiesis.

The erythrocyte: morphology, metabolism, aging and removal.

Anemias. Classification, clinical and laboratorial presentation and treatment: Iron deficiency anemia; sideroblastic anemia; anemia of chronic and neoplasic diseases; megaloblastic and non-megaloblastic macrocytic anemia; hemolytic anemia: talassemia and other hemoglobinopathies, hereditary spherocytosis and eliptocytosis; glucose-6-phosphate dehydrogenase deficiency; hemolytic disease of the newborn. Genetic studies for hereditary anemia.

Erythrocyte blood groups. ABO and Rhesus systems. Transfusional and feto-maternal aloimunisation. Blood transfusion.

Hemostasis: primary hemostasis, coagulation and fibrinolysis. Hemostatic disturbances.

Leukocytes and their benign disorders.

Hematologic malignancies: acute lymphoid and myeloid leukemia; chronic lymphoid and myeloid leukemia; myeloproliferative neoplasms; myelodisplastic syndromes; Hodgkin lymphoma and non-Hodgkin lymphomas; multiple myeloma. Infectious mononucleosis.   

Laboratorial program:
Basic hematological study. Reticulocyte count. Cases of anemia and leukocyte benign disorders. Identification of hematopoietic precursors in bone marrow and peripheral blood smears. Evaluation of ABO and Rhesus blood group.

 

Mandatory literature

Hillman Robert S.; Hematology in clinical practice: a guide to diagnosis and management. ISBN: 0-07-137502-3
Hoffbrand A. Victor; Hoffbrand.s essential haematology. ISBN: 978-1-118-40867-4
Kaushansky Kenneth 070; Williams hematology. ISBN: 978-0-07-183300-4

Complementary Bibliography

Hoffbrand Victor A.; Color atlas of clinical hematology. ISBN: 0-7234-3115-9
Dacie J. V.; Practical Haematology. ISBN: 0 443 01262 8
Williams William J.; Hematology. ISBN: 0-07-070377-9
Lewis S. Mitchell ed.; Dacie and Lewis practical haematology. ISBN: 0-443-06377-X
Lee G. Richard; Wintrobe.s clinical hematology. ISBN: 0-8121-1188-5
Hoffbrand A. Victor 340; Postgraduate haematology. ISBN: 978-1-118-85432-7

Teaching methods and learning activities

 

In the first class the students are informed about the teoric and laboratorial content of the curricular unit, the evaluation and recommended bibliography. Lectures are supported by illustrating slideshow. Along the classes, by applying to clinic hematologic websites, clinical cases illustrating the pathologies under study will be presented and discussed.

The evaluation will be with a final exam. The laboratorial evaluation takes place in the last laboratorial class and may include any of the assays performed along the laboratorial classes. The student must have 9.5 out of 20 to apply for the final exam. This final exam will evaluate knowledge from teoric and laboratory classes. The student must have 9.5 out of 20 to be approved (there are no oral exams).

The final mark will be calculated according to:
80% of the teoric component  + 20% of the mark from the laboratorial component

 

Evaluation Type

Distributed evaluation with final exam

Assessment Components

designation	Weight (%)
Exame	80,00
Trabalho laboratorial	20,00
Total:	100,00

Amount of time allocated to each course unit

designation	Time (hours)
Estudo autónomo	110,00
Frequência das aulas	52,00
Total:	162,00

Eligibility for exams

The attendance of the laboratory classes is compulsory. In order to obtain frquency for the curricular unit of Hematology, students must attend 2/3 of the planned laboratorial classes.

Calculation formula of final grade

 

The final note will be calculated according to:

80% of the mark from the teoric component+ 20% of themark of the laboratorial component

 

Observations

There may be changes to the laboratory program, depending on the progression of the panedemia COVID-19