Haematology II

Code:

MAC07008

Acronym:

HEM2

Keywords
Classification	Keyword
OFICIAL	Health Sciences

Instance: 2020/2021 - SP

Active?	Yes
Responsible unit:	Biochemistry Laboratory
Course/CS Responsible:	MSc in Clinical Analysis

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MAC	16	Official Curriculum	1	-	6	56	162

Teaching language

Portuguese

Objectives

The CU of Hematology II aims to study the hemostatic and transfusional processes, leukocyte physiopathology and the hematologic malignancies. Moreover, based on the theoric knowledge, the student should be able to understand plan and analyze a laboratorial study to evaluate a patient with hematologic malignancies.

Learning outcomes and competences

The teoric componente of this curricular unit aims to endow the students with hematologic,   biochemical, physiological, immunological and genetic knowledge to understand the mechanisms involved in the development of hemostatic disturbances, hematologic malignancies and, also, the blood group systems. This knowledge will enable also the student for a better understanding of the clinical and laboratorial findings, crucial for the diagnosis and prognosis of these pathologies, and of its treatment.

Alongside, in the laboratorial component of this curricular unit, the student will perform hematologic studies, usually used for the diagnosis of hemostatic disturbances, hematologic malignancies and, also, to the blood groups. The presentation and discussion of clinical cases to illustrate the pathologies under study, will contribute to a better linkage between teoric and laboratorial knowledge and also to develop student skills for resolution and analysis of the studies of a patient with hemostatic disturbances, or disturbances suggesting an hematologic malignancy.

Working method

Presencial

Program

Erythrocyte blood groups. ABO and Rhesus systems. Transfusional and feto-maternal aloimunisation.

Blood transfusion.

Hemostasis: primary hemostasis, coagulation and fibrinolysis. Hemostatic disturbances.

Leukocytes and their benign disorders.

Hematologic malignancies: etiology and genetics, support and specific therapies. Clinical features and laboratory findings, treatment and prognosis of acute lymphoid and myeloid leukemia. Clinical features and laboratory findings, treatment and prognosis of chronic lymphoid and myeloid leukemia. Myeloproliferative neoplasms. Myelodisplastic syndromes. Clinical features and laboratory findings, Clinical staging, treatment and prognosis of Hodgkin lymphoma. Non-Hodgkin lymphomas. Multiple myeloma.

Flow cytometry applied to the study of hematologic malignancies.

Identification of hematopoietic precursors in bone marrow and peripheral blood smears. Evaluation of ABO and Rhesus blood group.

Presentation and discussion of clinical cases of hematologic malignancies.

Mandatory literature

Hoffbrand AV; Essential Haematology, Wiley-Blackwell, 2011. ISBN: 978-1-4051-9890-5
Hillman Robert S; Hematology in Clinical Practice: a guide to diagnosis and management. ISBN: 0-07-137502-3

Complementary Bibliography

Hoffbrand AV; Color Atlas of Clinical Hematology. ISBN: 0-7234-3115-9
Hoffbrand AV; Postgraduate Hematology, 2016
Beutler E; Williams Hematology
Hematology; Williams William J
Lewis S, Mitchell; Dacie and Lewis Practical haematology
Lee G Richard; Wintrobe's Clinical Hematology

Teaching methods and learning activities

In the first class the students are informed about the teoric and laboratorial content of the curricular unit, the evaluation and recommended bibliography.
Lectures are supported by illustrating slideshow. Along the classes, by applying to clinic hematologic websites, the students will present and discuss clinical cases illustrating the pathologies under study.

In the laboratorial class the student will perform, individually, the hematologic evaluations under the scope of the curricular unit.

Attendance to lectures and laboratory classes is mandatory classes (at least for 75% of the classes).
The evaluation will be distributed, with a final exam. Attendance will be considered in the evaluation. The laboratorial evaluation takes place in the last laboratorial class and may include any of the assays performed along the laboratorial classes. The student must have 9.5 out of 20 to apply for the final written exam. This final exam will evaluate knowledge from teoric and laboratory classes. The student must have 9.5 out of 20 to be approved.

 

Software

não aplicável

Evaluation Type

Distributed evaluation with final exam

Assessment Components

designation	Weight (%)
Exame	80,00
Trabalho laboratorial	20,00
Total:	100,00

Amount of time allocated to each course unit

designation	Time (hours)
Apresentação/discussão de um trabalho científico	0,00
Estudo autónomo	128,50
Frequência das aulas	33,50
Trabalho laboratorial	0,00
Total:	162,00

Eligibility for exams

Attendance to at least for 75% of the classes

Calculation formula of final grade

The final mark (0-20) will be calculated according to:
80% of the mark from the wrritten exam + 20% of the mark of the laboratorial exam

Classification improvement

At the time of appeal with the final exam.

Observations

There may be changes to the program, due to the evolution of pandemia.