Haematology I

Code:

MAC07002

Acronym:

HEM1

Keywords
Classification	Keyword
OFICIAL	Health Sciences

Instance: 2020/2021 - SP

Active?	Yes
Responsible unit:	Biochemistry Laboratory
Course/CS Responsible:	MSc in Clinical Analysis

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MAC	17	Official Curriculum	1	-	6	56	162

Teaching language

Portuguese

Objectives

The aim of Hematology I is to study the clinical and laboratorial approach for hematological evaluation of a patient, to study the hematopoietic process, erythrocyte physiopathology and anemias, giving a particular emphasis to the most prevalent erythrocyte pathologies in Portugal. Moreover, based on the theoric knowledge, the student should be able to understand and perform the hematological studies needed for the first approach to a hematological patient and to its correct reading and interpretation.

Learning outcomes and competences

The teoric componente of this curricular unit aims to endow the students with hematologic,   biochemical, physiological, immunological and genetic knowledge to understand the mechanisms involved in blood cell production and in the development of erythrocyte pathologies. This knowledge will enable also the student for a better understanding of the clinical and laboratorial findings, crucial for the diagnosis and prognosis of these pathologies, and of its treatment.

Alongside, in the laboratorial component of this curricular unit, the student will perform hematologic studies, usually used for the diagnosis of hematologic disorders. The presentation and discussion of clinical cases to illustrate the pathologies under study, will contribute to a better linkage between teoric and laboratorial knowledge and also to develop student skills for resolution and analysis of the studies of a patient with anemia or other erythrocyte pathology.

Working method

Presencial

Program

Hematopoiesis. Laboratorial approach for hematologic studies. The erythrocyte: morphology, membrane and cytoplasm constituents, metabolism, aging and removal.

Physiological adptive mechanisms, clinical and symptomatology of anemia. Anemia classification. Iron, vitamin B12 and folic acid metabolisms.  Clinical and laboratorial presentation of different anemia, and treatment. Iron deficiency anemia; sideroblastic anemia; anemia of chronic and neoplasic diseases; megaloblastic and non-megaloblastic macrocytic anemia; hemolytic anemia: talassemia and other hemoglobinopathies, hereditary spherocytosis and eliptocytosis; glucose-6-phosphate dehydrogenase deficiency; hemolytic disease of the newborn.

Flow cytometry applied to the study of anemia.

Genetic studies apllied to diagnosis of erythroenzyme defficiencies, thalassemia and hemoglobinopathies, and iron disturbances.

Basic hematologic laboratorial studies, reticulocyte count and laboratorial studies of different types of anemia. 

Mandatory literature

Hoffbrand AV; Essential Haematology, Wiley-Balckwell, 2011. ISBN: ISBN: 978-1-4051-9890-5
Hillman Robert S; Hematology in Clinical Practice: a guide to diagnosis and management. ISBN: 0-07-137502-3

Complementary Bibliography

Hoffbrand AV; Color Atlas of Clinical Hematology. ISBN: 0-7234-3115-9
Hoffbrand AV; Postgraduate Hematology, 2016
Beutler E; Williams Hematology
Williams William J; Hematology
Lewis S, Mitchell; Dacie and Lewis Practical haematology
Lee G Richard; Wintrobe's Clinical Hematology

Teaching methods and learning activities

In the first class the students are informed about the teoric and laboratorial content of the curricular unit, the evaluation and recommended bibliography. Lectures are supported by illustrating slideshow. Along the classes, by applying to clinic hematologic websites, the students will present and discuss clinical cases illustrating the pathologies under study. 

In the first laboratorial class the student will perform blood collection and the others he will perform individually the hematologic evaluations under the scope of the curricular unit.

Attendance to lectures and laboratory classes is  mandatory (75% of the classes). The evaluation will be performed by written final exam, including knowledge from teoric and laboratory classes.    

The student must have 9.5 out of 20 to be approved.

Software

não aplicável

Evaluation Type

Evaluation with final exam

Assessment Components

designation	Weight (%)
Exame	100,00
Total:	100,00

Amount of time allocated to each course unit

designation	Time (hours)
Apresentação/discussão de um trabalho científico	0,00
Elaboração de projeto	0,00
Elaboração de relatório/dissertação/tese	0,00
Estudo autónomo	118,50
Frequência das aulas	43,42
Realização de Estágio	0,00
Trabalho de campo	0,00
Trabalho de investigação	0,00
Trabalho escrito	0,00
Total:	161,92

Eligibility for exams

Attendanceat least for 75% of the classes

Calculation formula of final grade

final mark = mark in the written fnal exam

Classification improvement

At the time of appeal with the final exam

Observations