Pharmacology I

Code:

MI073229

Acronym:

FCOL1

Keywords
Classification	Keyword
OFICIAL	Health Sciences

Instance: 2019/2020 - 2S

Active?	Yes
Web Page:	https://moodle.up.pt/course/view.php?id=1109
Responsible unit:	Pharmacology Laboratory
Course/CS Responsible:	MSc in Pharmaceutical Sciences

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MICF	177	Official Curriculum	3	-	6	65	162

Teaching language

Suitable for English-speaking students

Objectives

LEARNING OUTCOMES
At the conclusion of this curricular unit, students should understand the principles of Pharmacology, namely the general mechanisms of drug-receptor interactions and the qualitative and quantitative ways of characterizing the action of drugs. It should also know the general principles of pharmacokinetics, to understand how the organism, through the mechanisms of metabolization or through the barriers, influences ADME (Absorption, Distribution, Metabolization and Excretion) of drugs. Students should also be able to understand the determinants that influence the population response to a drug and to interpret them in the light of the pharmacodynamic and pharmacodynamic conditions.
In the Pharmacology of organs and systems, students should be able to identify the main intervention sites in neuropharmacology, to know the main groups of drugs and the pharmacological basis for their use in pharmacotherapy.

In the laboratory component, the student should be familiar with the general requirements for pharmacodynamic and clinical trials.

Learning outcomes and competences

EXPECTED OUTCOME 
Prepare individuals that: 
1) Know the general principles of Pharmacology; 
2) Are capable of expressing critical and scientific opinions on the validity and risk/benefit of using drugs belonging to the studied therapeutic groups; 
3) Are capable of applying the general principles to new pharmacological contexts.

Working method

B-learning

Pre-requirements (prior knowledge) and co-requirements (common knowledge)

Program

PROGRAM
THEORY CLASSES
1. The principles of general Pharmacology
1.1. Pharmacodynamics
1.2. Pharmacokinetics
1.3 Factors that determine individual intervariability in the response to drugs

2. Drugs acting on the nervous system
2.1. Drugs acting at the autonomic and somatic nervous system
2.1.1. Neurotransmission at the autonomic and somatic nervous system
2.1.2. Muscarinic agonists and antagonists
2.1.2.1 Anticholinesterase drugs
2.1.3. Drugs acting at the neuromuscular junction and autonomic ganglia
2.1.4 Adrenergic transmission
2.2. Drugs acting on the CNS
2.2.1. Sedative-hypnotic drugs
2.2.2. Antidepressant drugs
2.2.3. Antipsychotic agents
2.2.4. Antiparkinsónicos e outros fármacos com utilidade em doenças neurodegenerativas
2.2.5. Drugs effective in the therapy of the epilepsies
2.2.6. General and local anesthetics
2.2.7. Analgesics

LABORATORIAL CLASSES
1. Introduction to experimenal pharmacology
2. Information search and evidence demonstration
3. In vitro assays - cell culture models
4. Ex vivo assays - isolated organ models
Characterization of agonists. Concentration-response curves, calculation of EC50, pEC50. Potency and efficacy.
Characterization of antagonists. Competitive, non-competitive, reversible and irreversible antagonism. Schild's regression. Calculation of pA2 and pKb.
5. In vivo assays

Mandatory literature

Katzung Bertram G. ed.; Basic & clinical pharmacology. ISBN: 0-07-117968-2

Complementary Bibliography

Gilman Alfred Goodman ed.; Goodman and Gilman.s: the pharmacological basis of therapeutics. ISBN: 0-02-344710-9

Comments from the literature

Additional information will be made available through the Moodle platform.

Teaching methods and learning activities

Theorethical and laboratorial teaching, highlighting active learning via conceptual debates, planning, execution, analysis and discussion of laboratory experiments. Direct contact, complemented with e-learning and independent study.

Software

Microsoft Excel
GastroPlus

keywords

Health sciences > Neuroscience > Neurophysiology
Health sciences > Pharmacological sciences > Pharmacy
Health sciences > Pharmacological sciences > Clinical pharmacology

Evaluation Type

Distributed evaluation with final exam

Assessment Components

designation	Weight (%)
Exame	80,00
Trabalho laboratorial	20,00
Total:	100,00

Amount of time allocated to each course unit

designation	Time (hours)
Estudo autónomo	80,00
Frequência das aulas	65,00
Trabalho laboratorial	30,00
Total:	175,00

Eligibility for exams

According to assessment rules at FFUP

Calculation formula of final grade

FINAL MARK (0-20) = distributed assessment (0-4) + final exam (0-16)

---

The evaluation of the theoretical component will be carried out in two tests that will occur in the date scheduled by the Direction of the Course.
Failure to attend the first test requires a final exam.
The evaluation will be carried out through the Moodle platform through a questionnaire composed of multiple choice questions (2/3 of the total score) and a short answer (1/3 of the total score).
Students with special needs and those with mobility difficulties who have difficulty understanding the Portuguese language may request, in advance, the evaluation through a hand written questionnaire.

The evaluation of the laboratory component will be carried out in groups and through the presentation of a dossier resulting from the elaboration of written reports referring to the different modules presented in the laboratory classes (4 points).

Approval requires a minimum grade of 8 points in the theoretical component.

Special assessment (TE, DA, ...)

According to assessment rules at FFUP

Classification improvement

According to assessment rules at FFUP