Code: | MI073229 | Acronym: | FCOL1 |
Keywords | |
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Classification | Keyword |
OFICIAL | Health Sciences |
Active? | Yes |
Web Page: | https://moodle.up.pt/course/view.php?id=1109 |
Responsible unit: | Pharmacology Laboratory |
Course/CS Responsible: | MSc in Pharmaceutical Sciences |
Acronym | No. of Students | Study Plan | Curricular Years | Credits UCN | Credits ECTS | Contact hours | Total Time |
---|---|---|---|---|---|---|---|
MICF | 177 | Official Curriculum | 3 | - | 6 | 65 | 162 |
LEARNING OUTCOMES
At the conclusion of this curricular unit, students should understand the principles of Pharmacology, namely the general mechanisms of drug-receptor interactions and the qualitative and quantitative ways of characterizing the action of drugs. It should also know the general principles of pharmacokinetics, to understand how the organism, through the mechanisms of metabolization or through the barriers, influences ADME (Absorption, Distribution, Metabolization and Excretion) of drugs. Students should also be able to understand the determinants that influence the population response to a drug and to interpret them in the light of the pharmacodynamic and pharmacodynamic conditions.
In the Pharmacology of organs and systems, students should be able to identify the main intervention sites in neuropharmacology, to know the main groups of drugs and the pharmacological basis for their use in pharmacotherapy.
In the laboratory component, the student should be familiar with the general requirements for pharmacodynamic and clinical trials.
EXPECTED OUTCOME
Prepare individuals that:
1) Know the general principles of Pharmacology;
2) Are capable of expressing critical and scientific opinions on the validity and risk/benefit of using drugs belonging to the studied therapeutic groups;
3) Are capable of applying the general principles to new pharmacological contexts.
PROGRAM
THEORY CLASSES
1. The principles of general Pharmacology
1.1. Pharmacodynamics
1.2. Pharmacokinetics
1.3 Factors that determine individual intervariability in the response to drugs
2. Drugs acting on the nervous system
2.1. Drugs acting at the autonomic and somatic nervous system
2.1.1. Neurotransmission at the autonomic and somatic nervous system
2.1.2. Muscarinic agonists and antagonists
2.1.2.1 Anticholinesterase drugs
2.1.3. Drugs acting at the neuromuscular junction and autonomic ganglia
2.1.4 Adrenergic transmission
2.2. Drugs acting on the CNS
2.2.1. Sedative-hypnotic drugs
2.2.2. Antidepressant drugs
2.2.3. Antipsychotic agents
2.2.4. Antiparkinsónicos e outros fármacos com utilidade em doenças neurodegenerativas
2.2.5. Drugs effective in the therapy of the epilepsies
2.2.6. General and local anesthetics
2.2.7. Analgesics
LABORATORIAL CLASSES
1. Introduction to experimenal pharmacology
2. Information search and evidence demonstration
3. In vitro assays - cell culture models
4. Ex vivo assays - isolated organ models
Characterization of agonists. Concentration-response curves, calculation of EC50, pEC50. Potency and efficacy.
Characterization of antagonists. Competitive, non-competitive, reversible and irreversible antagonism. Schild's regression. Calculation of pA2 and pKb.
5. In vivo assays
Additional information will be made available through the Moodle platform.
Theorethical and laboratorial teaching, highlighting active learning via conceptual debates, planning, execution, analysis and discussion of laboratory experiments. Direct contact, complemented with e-learning and independent study.
designation | Weight (%) |
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Exame | 80,00 |
Trabalho laboratorial | 20,00 |
Total: | 100,00 |
designation | Time (hours) |
---|---|
Estudo autónomo | 80,00 |
Frequência das aulas | 65,00 |
Trabalho laboratorial | 30,00 |
Total: | 175,00 |
FINAL MARK (0-20) = distributed assessment (0-4) + final exam (0-16)
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The evaluation of the theoretical component will be carried out in two tests that will occur in the date scheduled by the Direction of the Course.
Failure to attend the first test requires a final exam.
The evaluation will be carried out through the Moodle platform through a questionnaire composed of multiple choice questions (2/3 of the total score) and a short answer (1/3 of the total score).
Students with special needs and those with mobility difficulties who have difficulty understanding the Portuguese language may request, in advance, the evaluation through a hand written questionnaire.
The evaluation of the laboratory component will be carried out in groups and through the presentation of a dossier resulting from the elaboration of written reports referring to the different modules presented in the laboratory classes (4 points).
Approval requires a minimum grade of 8 points in the theoretical component.