Physical-Chemistry

Code:

MI071207

Acronym:

QUIFIS

Keywords
Classification	Keyword
OFICIAL	Physical Sciences

Instance: 2017/2018 - 2S

Active?	Yes
Web Page:	https://sigarra.up.pt/ffup/pt/UCURR_GERAL.FICHA_UC_VIEW?pv_ocorrencia_id=366076
Responsible unit:	Applied Chemistry Laboratory
Course/CS Responsible:	MSc in Pharmaceutical Sciences

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MICF	239	Official Curriculum	1	-	6	65	162

Teaching language

Suitable for English-speaking students

Objectives

The aim of this discipline consists of the study of three large areas of physical-chemistry: thermodynamics, kinetics and binary heterogeneous systems. This therefore consists of the study of chemical thermodynamics – presentation of thermodynamic concepts, their chemical application and the study of biochemical thermodynamics – their application in the thermodynamic knowledge and interpretation of biological and microbiological phenomena, their application in the areas of life sciences and biotechnology. In relation to kinetics, this includes not only the study of chemical kinetics and catalysis but also enzymatic kinetics and enzymatic inhibition. Concerning heterogeneous systems, micelle and liposome systems will be studied, with special emphasis on those applicable as drug delivery systems or for the study of distribution, bioavailability and mechanism of action/interaction with biomembranes of drugs.

Learning outcomes and competences

Students are expected to acquire the following skills:

1) capacity to apply the knowledge acquired in physical-chemistry to other fields of knowledge present in the MSc in Pharmaceutical Sciences

2) ability to apply chemical concepts in determining physical-chemical parameter and in solving practical problems

 3) ability to present their arguments and solutions in a scientific and correct way.

Working method

Presencial

Pre-requirements (prior knowledge) and co-requirements (common knowledge)

Students should have knowledge of subject-matters taught in General and Inorganic Chemistry. Students should also have basic knowledge of Biochemistry.

Program

Unit 1 - Chemical and Biochemical Thermodynamics Concepts and thermodynamic definitions The zero law of thermodynamic The first law of thermodynamic Thermochemistry The second law of thermodynamic Gibbs function Free energy and equilibrium Application of Gibbs function and entropy to biological systems: coupled reactions, phosphate group transfer reactions, and proton transfer reactions. Biochemical Application of thermodynamics: active and passive transport, sodium-potassium pump, thermodynamics of glucose metabolism. Unit 2 – Kinetics Rate of reaction Rate law Reaction mechanisms and rate law Reaction mechanisms based on kinetics and thermodynamics parameters: alkane halogenation and SN1 and SN2 reactions Chemical Catalysis Unit 3- Enzyme kinetics and inhibition Unit 4 – Binary and heterogeneous systems Introduction to binary phase systems Phase diagrams Analytical applications Introduction to heterogeneous systems Definition of heterogeneous systems: micelles, vesicles, liposomes, membranes Importance of studying the interaction of drugs with heterogeneous systems Heterogeneous systems applied to pharmaceutical technology Drug delivery using heterogeneous systems Catalysis using heterogeneous systems Physico-chemical properties influencing the interaction of drugs with heterogeneous systems Methodologies for studying the interaction of drugs with heterogeneous systems as biomimetic models of lipidic membranes

Mandatory literature

Chang Raymond; Physical chemistry with applications to biological systems. ISBN: 0-02-321040-0
Atkins Peter; The^elements of physical chemistry. ISBN: 0-19-879290-5
João Sotomayor; Cinética Química, Lidel, 2003. ISBN: 972-757-251-0

Complementary Bibliography

Tinoco Ignacio 070; Physical chemistry: principles and applications in biological sciences. ISBN: 0-13-095943-X
Barrow Gordon M.; Physical chemistry for the life sciences. ISBN: 0-07-003858-9

Teaching methods and learning activities

Theoretical classes: 2 hours / week taught with the help of available audiovisuals. Practical classes: 1 hour/week. Resolution of application problems. Laboratory classes: 2 hours / week include experimental work related to the subject-matters taught in the theoretical classes. The tasks are undertaken in group and all experimental observations are register, with further calculus discussed at the end of the semester.

 

keywords

Physical sciences > Chemistry > Physical chemistry

Evaluation Type

Distributed evaluation with final exam

Assessment Components

designation	Weight (%)
Exame	79,00
Participação presencial	7,50
Trabalho laboratorial	13,50
Total:	100,00

Amount of time allocated to each course unit

designation	Time (hours)
Estudo autónomo	103,00
Frequência das aulas	39,00
Trabalho laboratorial	26,00
Total:	168,00

Eligibility for exams

The assiduity in the laboratorial classes is compulsory, as established in the Norms of Evaluation of the FFUP. The presence at the theoretical classes is not mandatory.

Calculation formula of final grade

This is the weighted average of the laboratorial classification (obtained during the semester as the distributed evalution or obtained in the practical test as part of the final exam), that contributes with 30%, and the written exam, that contributes with 70%. The lab evaluation is quantified (0 to 20) from the students’ performance during the lab classes, from the recording of experimental observations and associated calculus discussed in a class at the end of the semester (70%). The lab evaluation also comprehends answering some questions given in the written exam (30%). Regarding this last component, some points should be clarified:

a) Students with classification lower than 9.5 after the first call for written exam will not be approved. However, they can be approved in the second call for the written exam if a classification higher than 9.5 is obtained in the reevaluation.

b) If students do not attend to the second call for the written exam or if a classification lower than 9.5 is obtained in the reevaluation, they will not be approved. However, they can submit themselves to the practical test of the final exam in the following two years in order to get approval, as they attendance to the lab classes is considered valid under this period.

Approval at the laboratory evaluation is a pre-requisite for admission to the written test of the final exam. The students, who are lawfully allowed to not attend the experimental classes, and hence are not evaluated in a distributed way, will be compulsory expected to perform the practical test in the final exam.

The final exam is composed by two parts: Practical test – it comprehends all the subjects within the laboratorial component of this discipline. One of the experimental protocols will be performed, accompanied by the respective report. The classification should be given within 0 and 20. Besides exceptional cases under Law, the practical test will only be available to students that fulfilled the assiduity requirements and had a classification lower than 9.5 in the laboratory evaluation. Written test – it comprehends all the subjects within the discipline program that were taught. The classification should be given within 0 and 20. Students with classification lower than 8.0 are not approved. Students with classification higher than 8.0 are approved as long as the weighted average of the laboratorial and the written test classifications are equal or higher than 10.

Examinations or Special Assignments

The students, who are lawfully allowed to not attend the experimental classes, and hence are not evaluated in a distributed way, will be compulsory expected to perform the practical test and also the oral test in the final exam.

Special assessment (TE, DA, ...)

cf. current FFUP Evaluation Rules

Classification improvement

The students who wish to improve their own classification can make it through the written test of the final examination.