MEASUREMENT OF TROUGH-TO-PEAK RATIOS OF 4 ANTIHYPERTENSIVE DRUGS ON THE BASIS OF 24-H AMBULATORY BLOOD-PRESSURE MONITORING - DIFFERENT METHODS MAY GIVE DIFFERENT RESULTS

• Type: Article in International Scientific Journal
• Date: 1995

Authors

GAMA, G (Author) Other; SANTOS, A (Author) Other; POLONIA, J (Author) FMUP

Journal

Title: Journal of Human Hypertension

Vol. 9 No. 7

Pages: 575-580

ISSN: 0950-9240

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 13 Citations

Scopus - 21 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-001-GPH

Abstract (EN): With 24 h ambulatory blood pressure monitoring (ABPM), the trough-to-peak (T/P) ratios (corrected for placebo) of atenolol 100 mg, cilazapril 2.5 mg, enalapril 20 mg and nifedipine-GITS 30 mg administered once daily for 4 weeks were determined in four groups of hypertensive patients. T/P ratios were calculated by three different methods: directly from the curves that averaged all individual 24 h profiles (A); averaging all individual T/P ratios after ABPM data were averaged for each patient over either 1 h intervals (B) or 3 h intervals (C). Methods B and C produced different values of T/P which, for each drug, were significantly higher with method C. With method A, nifedipine appeared to have the higher T/P. With methods B and C (which in contrast to method A, permitted statistical comparisons), differences between nifedipine and the other drugs were not significant. Meanwhile, method B appears to adhere most closely to FDA guidelines by taking more into account the interindividual variability of BP profile. Thus, we suggest that precise guidelines for measuring T/P on the basis of ABPM are needed, whereas for the comparison between drugs, both the mean value of the T/P and its variance must be determined.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6