Using physics simulation to understand the biology process of ion channels

• Type: Article in International Scientific Journal
• Date: 2025

Authors

Hahn, D (Author) Other; Machado, NA (Author) Other; Carvalho, PS (Author) FCUP; Cruz, FADO (Author) Other

Journal

Title: Physics Education

Vol. 60

ISSN: 0031-9120

Publisher: Institute of Physics Publishing

Indexing

Scopus - 0 Citations

Other information

Authenticus ID: P-019-VAZ

DOI: 10.1088/1361-6552/adf7f9

Abstract (EN): This work presents a pedagogical proposal that employs the Circuit Construction Kit: DC computer simulation from the PhET platform to address Millman¿s theorem and facilitate the understanding of the principles involved in the electrical equilibrium of biological cells. The study models the cell membrane potential as a simplified electrical circuit, considering ion channels (Na+, K+, and Cl¿) as resistors and concentration gradients as voltage sources. Through simulation, the effects of varying ionic conductances on the resting potential are analysed, highlighting how the inactivation of the Cl¿ channel or changes in the conductances of Na+ and K+, aimed at restoring equilibrium, affect cellular homeostasis and excitability. We argue that the proposed approach promotes intuitive learning by reducing reliance on mathematical formalism and encouraging the application of physical concepts to real physiological contexts. The simulation has proven to be an effective teaching tool in health-related courses, fostering virtual experimentation and the qualitative interpretation of complex phenomena. © 2025 Elsevier B.V., All rights reserved.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 0