Functional cross-species conservation of guanylate-binding proteins in innate immunity

• Type: Another Publication in an International Scientific Journal
• Date: 2022-04

Authors

Joana Abrantes (Author) FCUP

Journal

The Journal is awaiting validation by the Administrative Services.

Title: MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Vol. 212

Pages: 141-152

ISSN: 0300-8584

Publisher: Springer

Indexing

ISI Web of Knowledge - 23 Citations

Scopus - 22 Citations

Other information

Authenticus ID: P-00W-DF7

DOI: 10.1007/s00430-022-00736-7

Abstract (EN): Guanylate binding proteins (GBPs) represent an evolutionary ancient protein family widely distributed among eukaryotes. They are interferon (IFN)-inducible guanosine triphosphatases that belong to the dynamin superfamily. GBPs are known to have a major role in the cell-autonomous innate immune response against bacterial, parasitic and viral infections and are also involved in inflammasome activation. Evolutionary studies depicted that GBPs present a pattern of gain and loss of genes in each family with several genes pseudogenized and some genes more divergent, indicative for the birth-and-death evolution process. Most species harbor large GBP gene clusters encoding multiple paralogs. Previous functional studies mainly focused on mouse and human GBPs, but more data are becoming available, broadening the understanding of this multifunctional protein family. In this review, we will provide new insights and give a broad overview about GBP evolution, conservation and their roles in all studied species, including plants, invertebrates and vertebrates, revealing how far the described features of GBPs can be transferred to other species.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12