Assessment of Tartrazine Diffusion Properties in Skeletal Muscle

• Type: Article in International Scientific Journal
• Date: 2026

Authors

Guerra, AR (Author) Other; Oliveira, LR (Author) Other; Rodrigues, GO (Author) Other; Pinheiro, MR (Author) Other; Maria Inês Barbosa de Carvalho (Author) FEUP; Tuchín, VV (Author) Other; Oliveira, LM (Author) Other

Journal

Title: IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS

Vol. 32

Pages: 1-8

ISSN: 1077-260X

Publisher: IEEE

Indexing

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Other information

Authenticus ID: P-01A-REB

DOI: 10.1109/jstqe.2025.3640959

Abstract (EN): Evaluating diffusion properties of novel optical clearing (OC) agents is critical for advancing medical imaging. Tartrazine (TTZ), a strong absorbing dye, has shown promise in enhancing tissue transparency, yet its diffusion properties remain uncharacterized. In this work, OC treatments with TTZ-water solutions with varying osmolarities were performed, and the diffusion times (tau) that characterize the tissue dehydration and the RI matching mechanisms were estimated. From kinetic T-c measurements during treatment, tau values of water and TTZ were estimated in muscles as 60.0 s and 416.0 s, respectively. Corresponding diffusion coefficients (D) were derived from sample thickness data measured during treatments where the unique fluxes of TTZ and water occur. The respective D values were then calculated as 1.9 x 10(-6) cm(2)/s for water and 3.6 x 10(-7) cm(2)/s for TTZ. These findings provide key insights into TTZ diffusion in skeletal muscle and support its potential as an effective OC agent.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8