Two genomes, one destiny: Mitophagy at the crossroads of inheritance and disease

• Type: Another Publication in an International Scientific Journal
• Date: 2025

Authors

Chung, CY (Author) Other; Singh, K (Author) Other; Pinho, BR (Author) Other; Jorge M A Oliveira (Author) FFUP; Duchen, MR (Author) Other

Journal

Title: Cell Chemical Biology

Vol. 32

Pages: 1439-1441

ISSN: 2451-9448

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-01A-TKA

DOI: 10.1016/j.chembiol.2025.11.010

Abstract (EN): Mechanisms ensuring mito-nuclear compatibility are poorly understood. In a recent study published in Science,(1) Frison et al. found that a mouse mitochondrial DNA (mtDNA) mutation can escape mitochondrial surveillance in embryogenesis by repressing the ubiquitin-proteasome system. Inhibition of USP30 restored ubiquitin-mediated mitophagy and reduced mutant burden, suggesting a potential therapeutic target for mtDNA disorders.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 3