Skin cancer chemoprevention: An overview

• Type: Another Publication in an International Scientific Journal
• Date: 2025

Authors

Bastos, M (Author) Other; Lucilia Saraiva (Author) FFUP; Marques, AC (Author) FFUP; Maria Helena Amaral (Author) FFUP

Journal

Title: Drug Discovery Today

Vol. 30

ISSN: 1359-6446

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-01A-A7N

DOI: 10.1016/j.drudis.2025.104493

Abstract (EN): The incidence of melanoma and non-melanoma skin cancers (NMSCs) is rising worldwide, with ultraviolet radiation as a primary cause. Although NMSCs are more common, melanoma remains the most challenging to treat because of its higher aggressiveness, late diagnosis, and recurrence after therapy. Sunscreens provide limited protection, highlighting the need for alternative solutions. Chemopreventive therapies targeting molecular pathways involved in melanoma progression have shown promise. Certain synthetic and natural nontoxic compounds can inhibit skin carcinogenesis during the initiation, promotion, and progression stages. This review discusses the effects of chemopreventive agents, including nonsteroidal antiinflammatory drugs (NSAIDs), statins, antioxidants, and vitamins, on skin cancer. Although substantial preclinical evidence suggests these strategies might prevent or delay melanoma, clinical studies confirming efficacy and longterm safety are still lacking.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 14