Optimization of quercetin - liposomal dry powders for pulmonary delivery using supercritical CO2-assisted spray drying

• Type: Article in International Scientific Journal
• Date: 2025

Authors

Costa, C (Author) Other; Liliana Grenho (Author) FMDUP; Casimiro, T (Author) Other; Gomes PS (Author) FMDUP; Fernandes MH (Author) FMDUP; Corvo, ML (Author) Other; Aguiar-Ricardo, A (Author) Other

Journal

Title: Journal of Supercritical Fluids

Vol. 222

ISSN: 0896-8446

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 0 Citations

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Other information

Authenticus ID: P-018-F5G

DOI: 10.1016/j.supflu.2025.106591

Abstract (EN): Quercetin exhibits anti-inflammatory and antioxidant properties. Incorporating quercetin into liposomes can overcome its limited water solubility and poor oral bioavailability, making it a promising candidate for treating inflammatory diseases. For pulmonary administration, supercritical CO2-assisted spray drying can be used to convert liposomal suspensions into dry powder formulations suitable for inhalation. However, the extraction power of scCO(2) can pose challenges on retaining the incorporation efficiency (IE) of this flavonoid in the lipid bilayer. This study focuses on optimizing quercetin's IE after drying using different liposomal lipid compositions with varying surface charges. The IE of quercetin into positively charged liposomes was 57 %. Additionally, the resulting powders had a mass median aerodynamic diameter of 1.7 mu m and a fine particle fraction (particle size < 5 m) of 63 %, indicating their suitability for inhalation. Cytotoxicity assays also revealed that both reconstituted liposomes and dry powder formulations were non-toxic to areolar fibroblast cells.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9