A glass-reinforced hydroxyapatite and surgical-grade calcium sulfate for bone regeneration: In vivo biological behavior in a sheep model

• Type: Article in International Scientific Journal
• Date: 2012

Authors

Paulo Pegado Cortez (Author) ICBAS; Marta Alves Silva (Author) Other; Marta Santos (Author) Other; Paulo Armada da Silva (Author) Other; Amrico Afonso (Author) FMDUP; Maria A Lopes (Author) FEUP; Jose Domingos Santos (Author) FEUP; Ana Colette Mauricio (Author) ICBAS

Journal

Title: Journal of Biomaterials Applications

Vol. 27 No. 2

Pages: 201-217

ISSN: 0885-3282

Publisher: SAGE

Indexing

ISI Web of Knowledge - 10 Citations

ISI Web of Science

Scopus - 17 Citations

Scientific classification

FOS: Engineering and technology > Environmental biotechnology

CORDIS: Technological sciences > Engineering > Biomaterial engineering

Other information

Authenticus ID: P-002-7JA

DOI: 10.1177/0885328211399479

Abstract (EN): A glass-reinforced hydroxyapatite (HA) composite (Bonelike (R)) was developed for bone grafting. This biomaterial is composed of a modified HA matrix with alpha- and beta-tricalcium phosphate secondary phases, resulting in higher solubility than single HA type of materials. Several in vitro and in vivo studies demonstrated that Bonelike (R) has a highly bioactive behavior, which was also confirmed by employing granular forms of this biomaterial in orthopedics and dental applications. However, a fast consolidation vehicle was needed to promote the fixation of Bonelike (R) granules if applied in larger defects or in unstable sites. Surgical-grade calcium sulfate (CS), which is widely recognized as a well-tolerated and inexpensive bone graft material, was the chosen vehicle to improve the handling characteristics of Bonelike (R) as it can be used in the form of a powder that is mixed with a liquid to form a paste that sets in situ. After application in non-critical monocortical defects in sheep, histological, and scanning electron microscopy evaluations demonstrated that Bonelike (R) associated to CS functioned as a very satisfactory scaffold for bone regeneration as it achieved synchronization of the ingrowing bone with biomaterial resorption and subsequent preservation of the bone graft initial volume. Therefore, our results indicate that CS is an effective vehicle for Bonelike (R) granules as it facilitates their application and does not interfere with their proven highly osteoconductive properties. In the opposite way, the incorporation of Bonelike (R) improves the bone regeneration capabilities of CS.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 17