Microbiome in cystic fibrosis: Shaping polymicrobial interactions for advances in antibiotic therapy

• Type: Article in International Scientific Journal
• Date: 2015

Authors

Susana P. Lopes (Author) Other; Nuno F. Azevedo (Author) FEUP; Maria O. Pereira (Author) Other

Journal

Title: Critical Reviews in Microbiology

Vol. 41 No. 3

Pages: 353-365

ISSN: 1040-841X

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 13 Citations

Scopus - 19 Citations

Scientific classification

FOS: Natural sciences > Biological sciences

Associated Projects

DNA mimics - Desenvolvimento e aplicação de mímicos de DNA para a rápida identificação de microrganismos patogénicos

Other information

Authenticus ID: P-00G-FH9

DOI: 10.3109/1040841x.2013.847898

Abstract (EN): Recent molecular methodologies have demonstrated a complex microbial ecosystem in cystic fibrosis (CF) airways, with a wide array of uncommon microorganisms co-existing with the traditional pathogens. Although there are lines of evidence supporting the contribution of some of those emergent species for lung disease chronicity, clinical significance remains uncertain for most cases. A possible contribution for disease is likely to be related with the dynamic interactions established between microorganisms within the microbial community and with the host. If this is the case, management of CF will only be successful upon suitable and exhaustive modulation of such mixed ecological processes, which will also be useful to predict the effects of new therapeutic interventions.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 13