| Summary: |
The pseudo-persistence and potential ecotoxicological effects of pharmaceuticals, their metabolites and transformation products occurring in the aquatic environment, is a matter of a great concern nowadays, especially in the case of antibiotic residues that may contribute to the antibiotic resistance. Thus, STAR project aims at promoting environmental prevention and safety, by exploring chiral fluorinated antibiotics as proof of concept, considering that most small molecules approved in the last years are either fluorinated and/or chiral, presenting a stable C-F bond and a potentially enantioselective bioactivity. Further, the enantioselective occurrence of antibiotics and/or metabolites may be related to antibiotic resistant bacteria (ARB) and resistance genes (ARG). Hence, STAR aims to deepen the current knowledge about antibiotic resistance, by addressing an important topic that has been neglected: the fundamental understanding of enantioselectivity of environmental processes that can impact the fate and behavior of pharmaceutical contaminants. |